Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894534537> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2894534537 abstract "Author(s): Netirojjanakul, Chawita | Advisor(s): Francis, Matthew B. | Abstract: Antibodies have been widely used in many biological applications, including reseach tools, imaging, and therapeutics, due to their excellent binding specificity and affinity. As therapeutics, the ability to elicit immune effector functions and plasma half-life extension through the function of the constant domain (Fc) render antibodies superior to small molecules in these aspects. This work describes the use of chemical-based bioconjugation techniques to develop novel bioconjugates from antibody fragments and full-sized antibodies for therapeutic and imaging purposes. The complex structures of this class of biomolecules -- with the presence of multiple polypeptide chains, extensive disulfide networks, and critically important glycosylation patterns -- make it difficult to manipulate these biomolecules in a controlled manner. Thus, protein modification techniques play important roles in enabling the development of these constructs. In this work, we discuss the generation of Fc-synthetic molecule hybrids as antibody mimics, full-sized antibody-synthetic molecule conjugates as bispecific antibodies, and MS2-antibody conjugates as targeted delivery vehicles. The ability to conjugate different moieties into one molecule provides the ability to shuffle and combine synergistic advantages of the component molecules." @default.
- W2894534537 created "2018-10-05" @default.
- W2894534537 creator A5013018872 @default.
- W2894534537 date "2014-01-01" @default.
- W2894534537 modified "2023-09-23" @default.
- W2894534537 title "Development and Applications of Well-Defined Antibody and Antibody Fragment Bioconjugates" @default.
- W2894534537 hasPublicationYear "2014" @default.
- W2894534537 type Work @default.
- W2894534537 sameAs 2894534537 @default.
- W2894534537 citedByCount "0" @default.
- W2894534537 crossrefType "journal-article" @default.
- W2894534537 hasAuthorship W2894534537A5013018872 @default.
- W2894534537 hasConcept C125823703 @default.
- W2894534537 hasConcept C134306372 @default.
- W2894534537 hasConcept C159654299 @default.
- W2894534537 hasConcept C171250308 @default.
- W2894534537 hasConcept C185592680 @default.
- W2894534537 hasConcept C192562407 @default.
- W2894534537 hasConcept C197336794 @default.
- W2894534537 hasConcept C203014093 @default.
- W2894534537 hasConcept C21951064 @default.
- W2894534537 hasConcept C23963754 @default.
- W2894534537 hasConcept C27256138 @default.
- W2894534537 hasConcept C2777313579 @default.
- W2894534537 hasConcept C3020495827 @default.
- W2894534537 hasConcept C33923547 @default.
- W2894534537 hasConcept C49853544 @default.
- W2894534537 hasConcept C51785407 @default.
- W2894534537 hasConcept C542903549 @default.
- W2894534537 hasConcept C55493867 @default.
- W2894534537 hasConcept C70721500 @default.
- W2894534537 hasConcept C86803240 @default.
- W2894534537 hasConceptScore W2894534537C125823703 @default.
- W2894534537 hasConceptScore W2894534537C134306372 @default.
- W2894534537 hasConceptScore W2894534537C159654299 @default.
- W2894534537 hasConceptScore W2894534537C171250308 @default.
- W2894534537 hasConceptScore W2894534537C185592680 @default.
- W2894534537 hasConceptScore W2894534537C192562407 @default.
- W2894534537 hasConceptScore W2894534537C197336794 @default.
- W2894534537 hasConceptScore W2894534537C203014093 @default.
- W2894534537 hasConceptScore W2894534537C21951064 @default.
- W2894534537 hasConceptScore W2894534537C23963754 @default.
- W2894534537 hasConceptScore W2894534537C27256138 @default.
- W2894534537 hasConceptScore W2894534537C2777313579 @default.
- W2894534537 hasConceptScore W2894534537C3020495827 @default.
- W2894534537 hasConceptScore W2894534537C33923547 @default.
- W2894534537 hasConceptScore W2894534537C49853544 @default.
- W2894534537 hasConceptScore W2894534537C51785407 @default.
- W2894534537 hasConceptScore W2894534537C542903549 @default.
- W2894534537 hasConceptScore W2894534537C55493867 @default.
- W2894534537 hasConceptScore W2894534537C70721500 @default.
- W2894534537 hasConceptScore W2894534537C86803240 @default.
- W2894534537 hasLocation W28945345371 @default.
- W2894534537 hasOpenAccess W2894534537 @default.
- W2894534537 hasPrimaryLocation W28945345371 @default.
- W2894534537 hasRelatedWork W1921766784 @default.
- W2894534537 hasRelatedWork W1995044751 @default.
- W2894534537 hasRelatedWork W2020248061 @default.
- W2894534537 hasRelatedWork W2317503393 @default.
- W2894534537 hasRelatedWork W2399877932 @default.
- W2894534537 hasRelatedWork W2566982980 @default.
- W2894534537 hasRelatedWork W2785471015 @default.
- W2894534537 hasRelatedWork W2786202881 @default.
- W2894534537 hasRelatedWork W2801421729 @default.
- W2894534537 hasRelatedWork W2803576547 @default.
- W2894534537 hasRelatedWork W2995857301 @default.
- W2894534537 hasRelatedWork W3009240909 @default.
- W2894534537 hasRelatedWork W3080540203 @default.
- W2894534537 hasRelatedWork W3081642245 @default.
- W2894534537 hasRelatedWork W3110009699 @default.
- W2894534537 hasRelatedWork W3113102068 @default.
- W2894534537 hasRelatedWork W3147019743 @default.
- W2894534537 hasRelatedWork W3163275570 @default.
- W2894534537 hasRelatedWork W3202343833 @default.
- W2894534537 hasRelatedWork W2414383012 @default.
- W2894534537 isParatext "false" @default.
- W2894534537 isRetracted "false" @default.
- W2894534537 magId "2894534537" @default.
- W2894534537 workType "article" @default.