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• W2894534998 abstract "Based on their biological activity natural products continue to represent optimal lead structures for the development of novel drug candidates. We focused on the syntheses of several derivatives of the triterpene asiatic acid and on the evaluation of their cytotoxic activity in a photometric sulforhodamin B assay. Especially, benzamide 2 and rhodamine B conjugate 11 show a distinct cytotoxicity for several human tumor cell lines, e.g. EC50 (A2780) = 110 ± 1 nM and EC50 (A2780) = 8 ± 2 nM, respectively. Interestingly, compound 11 showed for two human tumor cell lines (HT29 and 518A2) non-linear, bimodal dose-response relationships." @default.
• W2894534998 created "2018-10-05" @default.
• W2894534998 creator A5003277434 @default.
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• W2894534998 date "2018-11-01" @default.
• W2894534998 modified "2023-09-27" @default.
• W2894534998 title "Transformation of asiatic acid into a mitocanic, bimodal-acting rhodamine B conjugate of nanomolar cytotoxicity" @default.
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• W2894534998 doi "https://doi.org/10.1016/j.ejmech.2018.09.066" @default.
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• W2894534998 hasPublicationYear "2018" @default.
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