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- W2894538205 abstract "Mosquito control, integrated vector management, and insecticide resistance management approaches are constrained by the number of safe and effective insecticides that are registered for use and manufacture. Capitalizing on the RNA interference (RNAi) machinery to suppress genes of interest in mosquitoes could help to clear these roadblocks in the future. The RNAi pathway can be activated via RNA molecules with a double-stranded appearance (RNAi triggers), resulting in silencing of target genes with exceptional target specificity. This approach thereby provides a new paradigm for vector control that can be mediated entirely by natural, non-toxic chemistries that can provide control for nuisance and vector species while minimizing impacts on non-target organisms and the environment. Importantly, an RNAi-based system would provide a platform for rapid development and delivery of new RNAi triggers to control larval and adult mosquitoes, with the potential to tap into different physiologies and modes of action to thwart or respond to development of insecticide resistance. Here we highlight the armamentarium for mosquito control chemistries and propose that RNAi could be a valuable addition to existing and developing control strategies with some additional translational efforts to move the technology to the point of being field-applicable. We review the importance of RNAi trigger design, tissue distribution, and fate in mosquitoes to maximize gene suppression and thereby phenotypic impact. Finally, we discuss existing and burgeoning technologies that can be tailored for production and delivery of RNAi triggers in the field." @default.
- W2894538205 created "2018-10-05" @default.
- W2894538205 creator A5006208201 @default.
- W2894538205 creator A5085640281 @default.
- W2894538205 date "2018-01-01" @default.
- W2894538205 modified "2023-10-12" @default.
- W2894538205 title "Molecular and Nano-Scale Alternatives to Traditional Insecticides for<i>in Situ</i>Control of Mosquito Vectors" @default.
- W2894538205 cites W1138768165 @default.
- W2894538205 cites W1500916922 @default.
- W2894538205 cites W1558641922 @default.
- W2894538205 cites W1595037851 @default.
- W2894538205 cites W1611419331 @default.
- W2894538205 cites W1729017034 @default.
- W2894538205 cites W1889319720 @default.
- W2894538205 cites W1916491745 @default.
- W2894538205 cites W1954006000 @default.
- W2894538205 cites W1964866473 @default.
- W2894538205 cites W1964937345 @default.
- W2894538205 cites W1966506799 @default.
- W2894538205 cites W1968186266 @default.
- W2894538205 cites W1969655028 @default.
- W2894538205 cites W1973498157 @default.
- W2894538205 cites W1982067724 @default.
- W2894538205 cites W1982944995 @default.
- W2894538205 cites W1985692378 @default.
- W2894538205 cites W1987554430 @default.
- W2894538205 cites W1987610635 @default.
- W2894538205 cites W1989129419 @default.
- W2894538205 cites W1992563538 @default.
- W2894538205 cites W2003253840 @default.
- W2894538205 cites W2004669233 @default.
- W2894538205 cites W2007074180 @default.
- W2894538205 cites W2008747961 @default.
- W2894538205 cites W2011820928 @default.
- W2894538205 cites W2012454976 @default.
- W2894538205 cites W2012482502 @default.
- W2894538205 cites W2014434275 @default.
- W2894538205 cites W2018879535 @default.
- W2894538205 cites W2019443816 @default.
- W2894538205 cites W2022222466 @default.
- W2894538205 cites W2028638155 @default.
- W2894538205 cites W2030262874 @default.
- W2894538205 cites W2031047143 @default.
- W2894538205 cites W2032240604 @default.
- W2894538205 cites W2037616695 @default.
- W2894538205 cites W2039411469 @default.
- W2894538205 cites W2039772376 @default.
- W2894538205 cites W2041822372 @default.
- W2894538205 cites W2042176182 @default.
- W2894538205 cites W2043951241 @default.
- W2894538205 cites W2045130546 @default.
- W2894538205 cites W2054156026 @default.
- W2894538205 cites W2054295273 @default.
- W2894538205 cites W2054363760 @default.
- W2894538205 cites W2060775828 @default.
- W2894538205 cites W2069424384 @default.
- W2894538205 cites W2070564266 @default.
- W2894538205 cites W2074790779 @default.
- W2894538205 cites W2075816891 @default.
- W2894538205 cites W2079902244 @default.
- W2894538205 cites W2084621409 @default.
- W2894538205 cites W2091857676 @default.
- W2894538205 cites W2093198351 @default.
- W2894538205 cites W2093284342 @default.
- W2894538205 cites W2096847727 @default.
- W2894538205 cites W2100394661 @default.
- W2894538205 cites W2100614045 @default.
- W2894538205 cites W2101728241 @default.
- W2894538205 cites W2102201190 @default.
- W2894538205 cites W2114583830 @default.
- W2894538205 cites W2117895512 @default.
- W2894538205 cites W2121199768 @default.
- W2894538205 cites W2121440246 @default.
- W2894538205 cites W2121525230 @default.
- W2894538205 cites W2128806600 @default.
- W2894538205 cites W2130802206 @default.
- W2894538205 cites W2133750453 @default.
- W2894538205 cites W2141335907 @default.
- W2894538205 cites W2142238693 @default.
- W2894538205 cites W2142305917 @default.
- W2894538205 cites W2142733283 @default.
- W2894538205 cites W2147294427 @default.
- W2894538205 cites W2149562859 @default.
- W2894538205 cites W2152730479 @default.
- W2894538205 cites W2152993806 @default.
- W2894538205 cites W2154082780 @default.
- W2894538205 cites W2154166273 @default.
- W2894538205 cites W2166018960 @default.
- W2894538205 cites W2167420653 @default.
- W2894538205 cites W2168083509 @default.
- W2894538205 cites W2195497520 @default.
- W2894538205 cites W2236909218 @default.
- W2894538205 cites W2305813535 @default.
- W2894538205 cites W2406404683 @default.
- W2894538205 cites W2472136907 @default.
- W2894538205 cites W2509346014 @default.
- W2894538205 cites W2522355039 @default.
- W2894538205 cites W2531960710 @default.