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- W2894540772 abstract "Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels. Excess and chronic glucocorticoid exposure, however, causes metabolic syndrome including insulin resistance, dyslipidemia, and hyperglycemia. Studies in animal models of metabolic disorders frequently demonstrate that suppressing glucocorticoid signaling improves insulin sensitivity and metabolic profiles. Glucocorticoids convey their signals through an intracellular glucocorticoid receptor (GR), which is a transcriptional regulator. The adipocyte is one cell type that contributes to whole body metabolic homeostasis under the influence of GR. Glucocorticoids' functions on adipose tissues are complex. Depending on various physiological or pathophysiological states as well as distinct fat depots, glucocorticoids can either increase or decrease lipid storage in adipose tissues. In rodents, glucocorticoids have been shown to reduce the thermogenic activity of brown adipocytes. However, in human acute glucocorticoid exposure, glucocorticoids act to promote thermogenesis. In this article, we will review the recent studies on the mechanisms underlying the complex metabolic functions of GR in adipocytes. These include studies of the metabolic outcomes of adipocyte specific GR knockout mice and identification of novel GR primary target genes that mediate glucocorticoid action in adipocytes." @default.
- W2894540772 created "2018-10-05" @default.
- W2894540772 creator A5073272932 @default.
- W2894540772 creator A5075902955 @default.
- W2894540772 creator A5081991449 @default.
- W2894540772 date "2018-01-01" @default.
- W2894540772 modified "2023-10-18" @default.
- W2894540772 title "Glucocorticoid Receptor and Adipocyte Biology" @default.
- W2894540772 cites W1137470125 @default.
- W2894540772 cites W1761323037 @default.
- W2894540772 cites W1876389666 @default.
- W2894540772 cites W1965576057 @default.
- W2894540772 cites W1965585832 @default.
- W2894540772 cites W1966555021 @default.
- W2894540772 cites W1967964480 @default.
- W2894540772 cites W1968156583 @default.
- W2894540772 cites W1969024827 @default.
- W2894540772 cites W1979545505 @default.
- W2894540772 cites W1985336161 @default.
- W2894540772 cites W1989307078 @default.
- W2894540772 cites W1989505891 @default.
- W2894540772 cites W1991504003 @default.
- W2894540772 cites W1992511009 @default.
- W2894540772 cites W1994121001 @default.
- W2894540772 cites W1995288330 @default.
- W2894540772 cites W1999174748 @default.
- W2894540772 cites W2001789499 @default.
- W2894540772 cites W2007026899 @default.
- W2894540772 cites W2007625102 @default.
- W2894540772 cites W2008939841 @default.
- W2894540772 cites W2009250443 @default.
- W2894540772 cites W2011909690 @default.
- W2894540772 cites W2015237552 @default.
- W2894540772 cites W2017650269 @default.
- W2894540772 cites W2024838999 @default.
- W2894540772 cites W2030026929 @default.
- W2894540772 cites W2036845348 @default.
- W2894540772 cites W2050972898 @default.
- W2894540772 cites W2051894528 @default.
- W2894540772 cites W2058339004 @default.
- W2894540772 cites W2060090203 @default.
- W2894540772 cites W2062626144 @default.
- W2894540772 cites W2066202970 @default.
- W2894540772 cites W2067181732 @default.
- W2894540772 cites W2074237613 @default.
- W2894540772 cites W2080839684 @default.
- W2894540772 cites W2081615034 @default.
- W2894540772 cites W2083602312 @default.
- W2894540772 cites W2083905467 @default.
- W2894540772 cites W2088516315 @default.
- W2894540772 cites W2092020543 @default.
- W2894540772 cites W2094338116 @default.
- W2894540772 cites W2095853712 @default.
- W2894540772 cites W2098494341 @default.
- W2894540772 cites W2099807030 @default.
- W2894540772 cites W2101280449 @default.
- W2894540772 cites W2104246562 @default.
- W2894540772 cites W2115274616 @default.
- W2894540772 cites W2117268230 @default.
- W2894540772 cites W2119911216 @default.
- W2894540772 cites W2122987234 @default.
- W2894540772 cites W2125088870 @default.
- W2894540772 cites W2125990439 @default.
- W2894540772 cites W2127156523 @default.
- W2894540772 cites W2129008449 @default.
- W2894540772 cites W2132328706 @default.
- W2894540772 cites W2132358997 @default.
- W2894540772 cites W2133963705 @default.
- W2894540772 cites W2134602314 @default.
- W2894540772 cites W2136064817 @default.
- W2894540772 cites W2138376605 @default.
- W2894540772 cites W2138596564 @default.
- W2894540772 cites W2139956969 @default.
- W2894540772 cites W2143347137 @default.
- W2894540772 cites W2152199891 @default.
- W2894540772 cites W2152357501 @default.
- W2894540772 cites W2152599381 @default.
- W2894540772 cites W2156518031 @default.
- W2894540772 cites W2156597872 @default.
- W2894540772 cites W2157556149 @default.
- W2894540772 cites W2167807351 @default.
- W2894540772 cites W2169272555 @default.
- W2894540772 cites W2184379786 @default.
- W2894540772 cites W2210739940 @default.
- W2894540772 cites W2281454947 @default.
- W2894540772 cites W2294165115 @default.
- W2894540772 cites W2294629340 @default.
- W2894540772 cites W2338044761 @default.
- W2894540772 cites W2406158937 @default.
- W2894540772 cites W2414361303 @default.
- W2894540772 cites W2472017826 @default.
- W2894540772 cites W2507949874 @default.
- W2894540772 cites W2522460787 @default.
- W2894540772 cites W2537279868 @default.
- W2894540772 cites W2537546128 @default.
- W2894540772 cites W2538438764 @default.
- W2894540772 cites W2555264092 @default.
- W2894540772 cites W2564618761 @default.
- W2894540772 cites W2596687088 @default.
- W2894540772 cites W2605493286 @default.