FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894540967> ?p ?o ?g. }

• W2894540967 endingPage "466" @default.
• W2894540967 startingPage "459" @default.
• W2894540967 abstract "Background A complex inflammatory response mediates the systemic effects of burn shock. Disruption of the endothelial glycocalyx causes shedding of structural glycoproteins, primarily syndecan-1 (SDC-1), leading to endothelial dysfunction. These effects may be mitigated by resuscitative interventions. Materials and methods Sprague–Dawley rats were used to create small, medium, and large burns and uninjured controls. Three different intravenous resuscitation protocols were applied within each group: Lactated Ringer's (LR) alone, LR plus fresh frozen plasma (FFP), or LR plus albumin. Blood was serially collected, and plasma SDC-1 was quantified with enzyme-linked immunosorbent assay. In one cohort, Evan's Blue Dye (EBD) was administered and quantified in lung by spectrophotometry as a functional assay of vascular permeability. In a second cohort, intact SCD-1 was quantified by immunohistochemistry in lung tissue. Statistical analysis employed two-way analysis of variance with multiple comparisons and Student's t-test. Results EBD extraction from lung was significantly greater with higher injury severity versus controls. Extraction decreased significantly in large-burn animals with addition of FFP to LR versus LR-only; addition of albumin to LR did not decrease EBD extraction. Plasma SCD-1 increased in injured animals compared with controls, and changes correlated with injury severity in all resuscitation groups (significance, P < 0.05). Lung SCD-1 staining reflected the results in the EBD assay. Conclusions Addition of FFP, not of albumin, to post-burn resuscitation diminishes vascular leakage associated with large burns. Addition of colloid does not affect SDC-1 shedding as measured in plasma. Ongoing work will further define pathophysiologic mechanisms and potential therapeutic interventions to mitigate injury and promote repair of the endothelial glycocalyx." @default.
• W2894540967 created "2018-10-05" @default.
• W2894540967 creator A5012024406 @default.
• W2894540967 creator A5027737109 @default.
• W2894540967 creator A5030596322 @default.
• W2894540967 creator A5037682750 @default.
• W2894540967 creator A5054815816 @default.
• W2894540967 creator A5062766920 @default.
• W2894540967 creator A5063369009 @default.
• W2894540967 creator A5071958879 @default.
• W2894540967 date "2019-01-01" @default.
• W2894540967 modified "2023-10-12" @default.
• W2894540967 title "Plasma Ameliorates Endothelial Dysfunction in Burn Injury" @default.
• W2894540967 cites W1969319463 @default.
• W2894540967 cites W1985756708 @default.
• W2894540967 cites W2006006000 @default.
• W2894540967 cites W2012711792 @default.
• W2894540967 cites W2017465761 @default.
• W2894540967 cites W2018680532 @default.
• W2894540967 cites W2023000147 @default.
• W2894540967 cites W2036137330 @default.
• W2894540967 cites W2041619453 @default.
• W2894540967 cites W2064970256 @default.
• W2894540967 cites W2068708779 @default.
• W2894540967 cites W2070244277 @default.
• W2894540967 cites W2075065579 @default.
• W2894540967 cites W2075268453 @default.
• W2894540967 cites W2088106697 @default.
• W2894540967 cites W2123095004 @default.
• W2894540967 cites W2145415920 @default.
• W2894540967 cites W2152252241 @default.
• W2894540967 cites W2170982145 @default.
• W2894540967 cites W2230203535 @default.
• W2894540967 cites W2291619660 @default.
• W2894540967 cites W2325533054 @default.
• W2894540967 cites W2342606003 @default.
• W2894540967 cites W2409402116 @default.
• W2894540967 cites W2515415806 @default.
• W2894540967 cites W2731231997 @default.
• W2894540967 doi "https://doi.org/10.1016/j.jss.2018.08.027" @default.
• W2894540967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30502286" @default.
• W2894540967 hasPublicationYear "2019" @default.
• W2894540967 type Work @default.
• W2894540967 sameAs 2894540967 @default.
• W2894540967 citedByCount "32" @default.
• W2894540967 countsByYear W28945409672019 @default.
• W2894540967 countsByYear W28945409672020 @default.
• W2894540967 countsByYear W28945409672021 @default.
• W2894540967 countsByYear W28945409672022 @default.
• W2894540967 countsByYear W28945409672023 @default.
• W2894540967 crossrefType "journal-article" @default.
• W2894540967 hasAuthorship W2894540967A5012024406 @default.
• W2894540967 hasAuthorship W2894540967A5027737109 @default.
• W2894540967 hasAuthorship W2894540967A5030596322 @default.
• W2894540967 hasAuthorship W2894540967A5037682750 @default.
• W2894540967 hasAuthorship W2894540967A5054815816 @default.
• W2894540967 hasAuthorship W2894540967A5062766920 @default.
• W2894540967 hasAuthorship W2894540967A5063369009 @default.
• W2894540967 hasAuthorship W2894540967A5071958879 @default.
• W2894540967 hasConcept C113045295 @default.
• W2894540967 hasConcept C126322002 @default.
• W2894540967 hasConcept C126894567 @default.
• W2894540967 hasConcept C141071460 @default.
• W2894540967 hasConcept C142724271 @default.
• W2894540967 hasConcept C16685009 @default.
• W2894540967 hasConcept C2776125364 @default.
• W2894540967 hasConcept C2776782833 @default.
• W2894540967 hasConcept C2777714996 @default.
• W2894540967 hasConcept C2778165595 @default.
• W2894540967 hasConcept C2780972559 @default.
• W2894540967 hasConcept C2993242423 @default.
• W2894540967 hasConcept C42219234 @default.
• W2894540967 hasConcept C71924100 @default.
• W2894540967 hasConcept C90924648 @default.
• W2894540967 hasConceptScore W2894540967C113045295 @default.
• W2894540967 hasConceptScore W2894540967C126322002 @default.
• W2894540967 hasConceptScore W2894540967C126894567 @default.
• W2894540967 hasConceptScore W2894540967C141071460 @default.
• W2894540967 hasConceptScore W2894540967C142724271 @default.
• W2894540967 hasConceptScore W2894540967C16685009 @default.
• W2894540967 hasConceptScore W2894540967C2776125364 @default.
• W2894540967 hasConceptScore W2894540967C2776782833 @default.
• W2894540967 hasConceptScore W2894540967C2777714996 @default.
• W2894540967 hasConceptScore W2894540967C2778165595 @default.
• W2894540967 hasConceptScore W2894540967C2780972559 @default.
• W2894540967 hasConceptScore W2894540967C2993242423 @default.
• W2894540967 hasConceptScore W2894540967C42219234 @default.
• W2894540967 hasConceptScore W2894540967C71924100 @default.
• W2894540967 hasConceptScore W2894540967C90924648 @default.
• W2894540967 hasLocation W28945409671 @default.
• W2894540967 hasLocation W28945409672 @default.
• W2894540967 hasOpenAccess W2894540967 @default.
• W2894540967 hasPrimaryLocation W28945409671 @default.
• W2894540967 hasRelatedWork W1964671558 @default.
• W2894540967 hasRelatedWork W2014071500 @default.
• W2894540967 hasRelatedWork W2016766779 @default.
• W2894540967 hasRelatedWork W2060853010 @default.
• W2894540967 hasRelatedWork W2329248088 @default.

• next