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- W2894557318 abstract "Introduction: Role of adjuvant therapy for resected gallbladder cancer remains unclear. There are no randomized trials to guide clinicians in this regard and retrospective studies remain split on efficacy of adjuvant treatment options. Method: The National Cancer Data Base (NCDB) was queried for patients with non-metastatic, resected gallbladder cancer diagnosed between 2004 and 2013. Baseline characteristics were compared using chi-square test and factors associated with adjuvant chemotherapy administration were analyzed using multivariate logistic regression model. Results: A total of 4486 patients were identified. Majority of the patients were >65 years of age (65.2%). In the full cohort analysis, patients who received adjuvant chemotherapy were more likely to be: younger, of Hispanic ethnicity, with no comorbidities, diagnosed from 2010-2013, with poorly differentiated histology, pT3, pN1, undergoing radical resection and receiving adjuvant radiation (p < 0.05). Subgroup analysis of patients receiving chemotherapy was done which demonstrated higher odds of single-agent chemotherapy administration among patients who: were elderly, diagnosed from 2004–2009, had well differentiated histology, pT1 & pN0 disease, belonged to the lowest income quartile and received adjuvant radiation (p < 0.05). [Table 1] Conclusions: In patients with resected gallbladder cancer, receipt of adjuvant chemotherapy is affected by several patient- and disease-specific factors and not just age alone." @default.
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- W2894557318 date "2018-09-01" @default.
- W2894557318 modified "2023-10-05" @default.
- W2894557318 title "Is age alone a predictor for receipt of adjuvant chemotherapy in patients with resected gallbladder cancer?" @default.
- W2894557318 doi "https://doi.org/10.1016/j.hpb.2018.06.1408" @default.
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