FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894560993> ?p ?o ?g. }

• W2894560993 endingPage "862" @default.
• W2894560993 startingPage "856" @default.
• W2894560993 abstract "The oral glucose tolerance test (OGTT) is considered the most useful method for diagnosing active acromegaly and for patient follow-up after neurosurgery. Despite its widespread use, only a few small studies have so far focused on patients' clinical features associated with different GH responsiveness to OGTT.We aimed to investigate the association between glucose-induced GH response and endocrine profiles, clinical manifestations, and response to therapy in a large cohort of patients with acromegaly.According to GH response to OGTT, patients were grouped as paradoxical (GH-Par) or nonparadoxical (GH-NPar), and their clinical and pathological features were compared in terms of pituitary tumor size, invasiveness, biochemical profiles, and response to therapy.The study concerned 496 patients with acromegaly. At diagnosis, those with GH-Par (n = 184) were older than those with GH-NPar (n = 312) (mean ± SD, 44.1 ± 13.7 years vs 40.5 ± 12.7 years; P < 0.01) and had smaller tumors (0.82 vs 1.57 cm3; P < 0.01) that less frequently invaded the cavernous sinus (15% vs 27%; P < 0.01). The GH-Par group also had a higher basal GH per volume ratio (14.3 vs 10.5 μg/L ⋅ cm3; P < 0.05) and a lower incidence of hyperprolactinemia (17% vs 30%; P < 0.01) than the GH-NPar group. Importantly, the GH-Par group had a higher rate of remission in response to somatostatin analogues (52% vs 26%; P < 0.01) and a more marked drop in IGF-1 and GH after 6 months of therapy.Our data strongly suggest that serum GH responsiveness to oral glucose challenge reflects some important biological features of pituitary tumors and that the OGTT may have some prognostic value." @default.
• W2894560993 created "2018-10-12" @default.
• W2894560993 creator A5010649029 @default.
• W2894560993 creator A5015192187 @default.
• W2894560993 creator A5018176262 @default.
• W2894560993 creator A5026695536 @default.
• W2894560993 creator A5030424357 @default.
• W2894560993 creator A5037867549 @default.
• W2894560993 creator A5042005891 @default.
• W2894560993 creator A5042420012 @default.
• W2894560993 creator A5046942308 @default.
• W2894560993 creator A5047774149 @default.
• W2894560993 creator A5048720703 @default.
• W2894560993 creator A5049028944 @default.
• W2894560993 creator A5051403646 @default.
• W2894560993 creator A5082249177 @default.
• W2894560993 creator A5082717632 @default.
• W2894560993 creator A5087750198 @default.
• W2894560993 date "2018-10-03" @default.
• W2894560993 modified "2023-10-16" @default.
• W2894560993 title "Paradoxical GH Increase During OGTT Is Associated With First-Generation Somatostatin Analog Responsiveness in Acromegaly" @default.
• W2894560993 cites W123434114 @default.
• W2894560993 cites W1504466718 @default.
• W2894560993 cites W1583056254 @default.
• W2894560993 cites W1590474435 @default.
• W2894560993 cites W1964036663 @default.
• W2894560993 cites W1974588462 @default.
• W2894560993 cites W1996064035 @default.
• W2894560993 cites W2014901068 @default.
• W2894560993 cites W2026293531 @default.
• W2894560993 cites W2028029176 @default.
• W2894560993 cites W2029448027 @default.
• W2894560993 cites W2030247016 @default.
• W2894560993 cites W2036142778 @default.
• W2894560993 cites W2039399257 @default.
• W2894560993 cites W2050264317 @default.
• W2894560993 cites W2050706080 @default.
• W2894560993 cites W2055856830 @default.
• W2894560993 cites W2064742571 @default.
• W2894560993 cites W2091535591 @default.
• W2894560993 cites W2095591038 @default.
• W2894560993 cites W2097427207 @default.
• W2894560993 cites W2104012869 @default.
• W2894560993 cites W2144743522 @default.
• W2894560993 cites W2152627121 @default.
• W2894560993 cites W2155465680 @default.
• W2894560993 cites W2161785085 @default.
• W2894560993 cites W2167641224 @default.
• W2894560993 cites W2484742435 @default.
• W2894560993 cites W2583082560 @default.
• W2894560993 cites W2587676995 @default.
• W2894560993 cites W2592756721 @default.
• W2894560993 cites W2737796269 @default.
• W2894560993 cites W2792283640 @default.
• W2894560993 doi "https://doi.org/10.1210/jc.2018-01360" @default.
• W2894560993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30285115" @default.
• W2894560993 hasPublicationYear "2018" @default.
• W2894560993 type Work @default.
• W2894560993 sameAs 2894560993 @default.
• W2894560993 citedByCount "21" @default.
• W2894560993 countsByYear W28945609932019 @default.
• W2894560993 countsByYear W28945609932020 @default.
• W2894560993 countsByYear W28945609932021 @default.
• W2894560993 countsByYear W28945609932022 @default.
• W2894560993 countsByYear W28945609932023 @default.
• W2894560993 crossrefType "journal-article" @default.
• W2894560993 hasAuthorship W2894560993A5010649029 @default.
• W2894560993 hasAuthorship W2894560993A5015192187 @default.
• W2894560993 hasAuthorship W2894560993A5018176262 @default.
• W2894560993 hasAuthorship W2894560993A5026695536 @default.
• W2894560993 hasAuthorship W2894560993A5030424357 @default.
• W2894560993 hasAuthorship W2894560993A5037867549 @default.
• W2894560993 hasAuthorship W2894560993A5042005891 @default.
• W2894560993 hasAuthorship W2894560993A5042420012 @default.
• W2894560993 hasAuthorship W2894560993A5046942308 @default.
• W2894560993 hasAuthorship W2894560993A5047774149 @default.
• W2894560993 hasAuthorship W2894560993A5048720703 @default.
• W2894560993 hasAuthorship W2894560993A5049028944 @default.
• W2894560993 hasAuthorship W2894560993A5051403646 @default.
• W2894560993 hasAuthorship W2894560993A5082249177 @default.
• W2894560993 hasAuthorship W2894560993A5082717632 @default.
• W2894560993 hasAuthorship W2894560993A5087750198 @default.
• W2894560993 hasBestOaLocation W28945609931 @default.
• W2894560993 hasConcept C126322002 @default.
• W2894560993 hasConcept C134018914 @default.
• W2894560993 hasConcept C2776297358 @default.
• W2894560993 hasConcept C2777433750 @default.
• W2894560993 hasConcept C2778024521 @default.
• W2894560993 hasConcept C2779306644 @default.
• W2894560993 hasConcept C2984496839 @default.
• W2894560993 hasConcept C71315377 @default.
• W2894560993 hasConcept C71924100 @default.
• W2894560993 hasConceptScore W2894560993C126322002 @default.
• W2894560993 hasConceptScore W2894560993C134018914 @default.
• W2894560993 hasConceptScore W2894560993C2776297358 @default.
• W2894560993 hasConceptScore W2894560993C2777433750 @default.
• W2894560993 hasConceptScore W2894560993C2778024521 @default.
• W2894560993 hasConceptScore W2894560993C2779306644 @default.

• next