FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894561194> ?p ?o ?g. }

• W2894561194 abstract "Chronic cigarette smoking is widely known to alter immune functions and compromise hose defense against microbial infection. Neutrophils play an essential role in the immune defense against microbial pathogens and also participate in the development of the inflammatory responses. However, there is limited information about the effects of cigarette smoking on neutrophil response. In this study, cultured bone marrow neutrophils were exposed to total particulate matter (TPM) from cigarette smoke. We found that TPM not only reduced LPS-induced TNFα production, but also suppressed neutrophil bactericidal activity. We also observed that TPM priming reduced the expression of NADPH oxidase component gp91 and iNOS, molecules important for bacterial killing. Mechanistically, we documented that TPM-primed neutrophils have reduced STAT1 activation following subsequent LPS challenge. STAT1 is a key transcription factor responsible for the expression of inflammatory genes as well as gp91 and iNOS. Collectively, reduced STAT1 activation and reduced NADPH oxidase/iNOS may potentially explain the compromised anti-microbial function of TPM-programmed neutrophils. Taken together, our findings reveal that the key innate immune neutrophil is subject to reprogramming by smoking to adopt an immune-suppressed state, potentially responsible for chronic smoking-mediated immunosuppression." @default.
• W2894561194 created "2018-10-12" @default.
• W2894561194 creator A5036511960 @default.
• W2894561194 creator A5076164186 @default.
• W2894561194 creator A5080577523 @default.
• W2894561194 creator A5089952959 @default.
• W2894561194 date "2018-10-04" @default.
• W2894561194 modified "2023-10-01" @default.
• W2894561194 title "Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke" @default.
• W2894561194 cites W1577251139 @default.
• W2894561194 cites W1757761368 @default.
• W2894561194 cites W1792186549 @default.
• W2894561194 cites W1878650141 @default.
• W2894561194 cites W1978557254 @default.
• W2894561194 cites W1980550304 @default.
• W2894561194 cites W1988435059 @default.
• W2894561194 cites W1991465901 @default.
• W2894561194 cites W1998915656 @default.
• W2894561194 cites W1999929050 @default.
• W2894561194 cites W2000125178 @default.
• W2894561194 cites W2002157461 @default.
• W2894561194 cites W2004979724 @default.
• W2894561194 cites W2006157497 @default.
• W2894561194 cites W2013065585 @default.
• W2894561194 cites W2027116213 @default.
• W2894561194 cites W2032227357 @default.
• W2894561194 cites W2040396783 @default.
• W2894561194 cites W2046665605 @default.
• W2894561194 cites W2048351247 @default.
• W2894561194 cites W2067973725 @default.
• W2894561194 cites W2069108330 @default.
• W2894561194 cites W2075578688 @default.
• W2894561194 cites W2094919522 @default.
• W2894561194 cites W2096330203 @default.
• W2894561194 cites W2128958971 @default.
• W2894561194 cites W2138537778 @default.
• W2894561194 cites W2138589888 @default.
• W2894561194 cites W2138824466 @default.
• W2894561194 cites W2140264378 @default.
• W2894561194 cites W2141701591 @default.
• W2894561194 cites W2145621175 @default.
• W2894561194 cites W2156107720 @default.
• W2894561194 cites W2169126410 @default.
• W2894561194 cites W2234245393 @default.
• W2894561194 cites W2321684484 @default.
• W2894561194 cites W2394732897 @default.
• W2894561194 cites W2395539393 @default.
• W2894561194 cites W2507370326 @default.
• W2894561194 cites W2549669347 @default.
• W2894561194 cites W2555713582 @default.
• W2894561194 cites W2611464104 @default.
• W2894561194 cites W4248797040 @default.
• W2894561194 doi "https://doi.org/10.3389/fimmu.2018.02274" @default.
• W2894561194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6180193" @default.
• W2894561194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30337926" @default.
• W2894561194 hasPublicationYear "2018" @default.
• W2894561194 type Work @default.
• W2894561194 sameAs 2894561194 @default.
• W2894561194 citedByCount "22" @default.
• W2894561194 countsByYear W28945611942019 @default.
• W2894561194 countsByYear W28945611942020 @default.
• W2894561194 countsByYear W28945611942021 @default.
• W2894561194 countsByYear W28945611942022 @default.
• W2894561194 countsByYear W28945611942023 @default.
• W2894561194 crossrefType "journal-article" @default.
• W2894561194 hasAuthorship W2894561194A5036511960 @default.
• W2894561194 hasAuthorship W2894561194A5076164186 @default.
• W2894561194 hasAuthorship W2894561194A5080577523 @default.
• W2894561194 hasAuthorship W2894561194A5089952959 @default.
• W2894561194 hasBestOaLocation W28945611941 @default.
• W2894561194 hasConcept C136449434 @default.
• W2894561194 hasConcept C185592680 @default.
• W2894561194 hasConcept C203014093 @default.
• W2894561194 hasConcept C2776178377 @default.
• W2894561194 hasConcept C2776914184 @default.
• W2894561194 hasConcept C2777003663 @default.
• W2894561194 hasConcept C2779719074 @default.
• W2894561194 hasConcept C48349386 @default.
• W2894561194 hasConcept C55493867 @default.
• W2894561194 hasConcept C86803240 @default.
• W2894561194 hasConcept C8891405 @default.
• W2894561194 hasConcept C89423630 @default.
• W2894561194 hasConceptScore W2894561194C136449434 @default.
• W2894561194 hasConceptScore W2894561194C185592680 @default.
• W2894561194 hasConceptScore W2894561194C203014093 @default.
• W2894561194 hasConceptScore W2894561194C2776178377 @default.
• W2894561194 hasConceptScore W2894561194C2776914184 @default.
• W2894561194 hasConceptScore W2894561194C2777003663 @default.
• W2894561194 hasConceptScore W2894561194C2779719074 @default.
• W2894561194 hasConceptScore W2894561194C48349386 @default.
• W2894561194 hasConceptScore W2894561194C55493867 @default.
• W2894561194 hasConceptScore W2894561194C86803240 @default.
• W2894561194 hasConceptScore W2894561194C8891405 @default.
• W2894561194 hasConceptScore W2894561194C89423630 @default.
• W2894561194 hasLocation W28945611941 @default.
• W2894561194 hasLocation W28945611942 @default.
• W2894561194 hasLocation W28945611943 @default.
• W2894561194 hasLocation W28945611944 @default.
• W2894561194 hasLocation W28945611945 @default.
• W2894561194 hasOpenAccess W2894561194 @default.

• next