FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894563804> ?p ?o ?g. }

• W2894563804 endingPage "159" @default.
• W2894563804 startingPage "145" @default.
• W2894563804 abstract "Ftz-f1 is an orphan member of the nuclear hormone receptor superfamily. A 20-hydroxyecdysone pulse allows ftz-f1 gene expression, which then regulates the activity of downstream genes involved in major developmental progression events. In honeybees, the expression of genes like vitellogenin (vg), prophenoloxidase and juvenile hormone-esterase during late pharate-adult development is known to be hormonally controlled in both queens and workers by increasing juvenile hormone (JH) titres in the presence of declining levels of ecdysteroids. Since Ftz-f1 is known for mediating intracellular JH signalling, we hypothesized that ftz-f1 could mediate JH action during the pharate-adult development of honeybees, thus controlling the expression of these genes. Here, we show that ftz-f1 has caste-specific transcription profiles during this developmental period, with a peak coinciding with the increase in JH titre, and that its expression is upregulated by JH and downregulated by ecdysteroids. RNAi-mediated knock down of ftz-f1 showed that the expression of genes essential for adult development (e.g. vg and cuticular genes) depends on ftz-f1 expression. Finally, a double-repressor hypothesis-inspired vg gene knock-down experiment suggests the existence of a positive molecular loop between JH, ftz-f1 and vg." @default.
• W2894563804 created "2018-10-12" @default.
• W2894563804 creator A5011624590 @default.
• W2894563804 creator A5022674796 @default.
• W2894563804 creator A5050097835 @default.
• W2894563804 creator A5050927295 @default.
• W2894563804 creator A5064495760 @default.
• W2894563804 creator A5067787348 @default.
• W2894563804 creator A5071566036 @default.
• W2894563804 creator A5091142981 @default.
• W2894563804 date "2018-10-30" @default.
• W2894563804 modified "2023-10-15" @default.
• W2894563804 title "Hormonal control and target genes of <i>ftz-f1 </i> expression in the honeybee <i>Apis mellifera</i> : a positive loop linking juvenile hormone, <i>ftz-f1</i> , and <i>vitellogenin</i>" @default.
• W2894563804 cites W1501652874 @default.
• W2894563804 cites W1544923801 @default.
• W2894563804 cites W1555081719 @default.
• W2894563804 cites W1783191235 @default.
• W2894563804 cites W1837064470 @default.
• W2894563804 cites W1966811134 @default.
• W2894563804 cites W1969114671 @default.
• W2894563804 cites W1973698985 @default.
• W2894563804 cites W1977936945 @default.
• W2894563804 cites W1979044784 @default.
• W2894563804 cites W1990444660 @default.
• W2894563804 cites W1992365463 @default.
• W2894563804 cites W1993387760 @default.
• W2894563804 cites W1997298696 @default.
• W2894563804 cites W1999631075 @default.
• W2894563804 cites W2001251162 @default.
• W2894563804 cites W2002706767 @default.
• W2894563804 cites W2005164888 @default.
• W2894563804 cites W2009745872 @default.
• W2894563804 cites W2009989509 @default.
• W2894563804 cites W2016489279 @default.
• W2894563804 cites W2020570884 @default.
• W2894563804 cites W2021534590 @default.
• W2894563804 cites W2023387306 @default.
• W2894563804 cites W2026455941 @default.
• W2894563804 cites W2027102545 @default.
• W2894563804 cites W2034132266 @default.
• W2894563804 cites W2038088162 @default.
• W2894563804 cites W2038204033 @default.
• W2894563804 cites W2038473444 @default.
• W2894563804 cites W2038506760 @default.
• W2894563804 cites W2040053707 @default.
• W2894563804 cites W2041973281 @default.
• W2894563804 cites W2047960568 @default.
• W2894563804 cites W2048133859 @default.
• W2894563804 cites W2053434076 @default.
• W2894563804 cites W2057140490 @default.
• W2894563804 cites W2057205002 @default.
• W2894563804 cites W2057886743 @default.
• W2894563804 cites W2059359550 @default.
• W2894563804 cites W2066430476 @default.
• W2894563804 cites W2068163284 @default.
• W2894563804 cites W2072525314 @default.
• W2894563804 cites W2078813514 @default.
• W2894563804 cites W2080361081 @default.
• W2894563804 cites W2081994757 @default.
• W2894563804 cites W2084665674 @default.
• W2894563804 cites W2085138441 @default.
• W2894563804 cites W2091764984 @default.
• W2894563804 cites W2097233732 @default.
• W2894563804 cites W2098035462 @default.
• W2894563804 cites W2103017472 @default.
• W2894563804 cites W2103697116 @default.
• W2894563804 cites W2108538959 @default.
• W2894563804 cites W2122992745 @default.
• W2894563804 cites W2123126118 @default.
• W2894563804 cites W2124388496 @default.
• W2894563804 cites W2126084294 @default.
• W2894563804 cites W2131796587 @default.
• W2894563804 cites W2138809852 @default.
• W2894563804 cites W2143695632 @default.
• W2894563804 cites W2152741970 @default.
• W2894563804 cites W2152889072 @default.
• W2894563804 cites W2362497075 @default.
• W2894563804 cites W2514973356 @default.
• W2894563804 cites W2552711960 @default.
• W2894563804 cites W2559136475 @default.
• W2894563804 cites W2750666305 @default.
• W2894563804 cites W2752964550 @default.
• W2894563804 cites W3021194431 @default.
• W2894563804 doi "https://doi.org/10.1111/imb.12541" @default.
• W2894563804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270498" @default.
• W2894563804 hasPublicationYear "2018" @default.
• W2894563804 type Work @default.
• W2894563804 sameAs 2894563804 @default.
• W2894563804 citedByCount "25" @default.
• W2894563804 countsByYear W28945638042019 @default.
• W2894563804 countsByYear W28945638042020 @default.
• W2894563804 countsByYear W28945638042021 @default.
• W2894563804 countsByYear W28945638042022 @default.
• W2894563804 countsByYear W28945638042023 @default.
• W2894563804 crossrefType "journal-article" @default.
• W2894563804 hasAuthorship W2894563804A5011624590 @default.
• W2894563804 hasAuthorship W2894563804A5022674796 @default.
• W2894563804 hasAuthorship W2894563804A5050097835 @default.

• next