Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894565839> ?p ?o ?g. }
- W2894565839 endingPage "390" @default.
- W2894565839 startingPage "383" @default.
- W2894565839 abstract "Abstract Hit, Lead & Candidate Discovery Drug repurposing has become a recent trend in drug development programs, where previously developed drugs are explored for hit and redeveloped into potential therapeutic agents for new diseases. Globally, in any drug development program, a series of molecules are synthesized and evaluated for the hypothesized activity. Hits are developed into lead molecules or drugs, whereas the negative ones are shelved in the lab with no immediate use. We in this project took the previously sidelined small chemical molecules to the next level of utility, where previously developed in‐house small molecules library are tested for the unexplored biological relevant activity. As biofilm formation and quorum sensing play a vital role in bacterial pathogenesis, we believe that they could be one of the most effective targets for antimicrobial agents. In this study, we report the evaluation of 50 different compounds for anti‐biofilm and anti‐quorum sensing activity against Pseudomonas aeruginosa . Out of the screened compounds, three hydrazine‐carboxamide hybrid derivatives showed promising anti‐biofilm property and inhibition of pyocyanin production without any direct antimicrobial activity and cytotoxicity issues. Hydrazine‐carboxamide hybrids can be a new class and promising leads for further anti‐biofilm and anti‐virulence development against microbial infections." @default.
- W2894565839 created "2018-10-12" @default.
- W2894565839 creator A5000109801 @default.
- W2894565839 creator A5014641314 @default.
- W2894565839 creator A5016891523 @default.
- W2894565839 creator A5041106147 @default.
- W2894565839 creator A5044024787 @default.
- W2894565839 creator A5049323293 @default.
- W2894565839 creator A5053717079 @default.
- W2894565839 creator A5064198618 @default.
- W2894565839 creator A5064778974 @default.
- W2894565839 creator A5076736155 @default.
- W2894565839 creator A5085371439 @default.
- W2894565839 date "2018-10-06" @default.
- W2894565839 modified "2023-09-25" @default.
- W2894565839 title "In-house chemical library<i>repurposing</i>: A case example for<i>Pseudomonas aeruginosa</i>antibiofilm activity and quorum sensing inhibition" @default.
- W2894565839 cites W1543621517 @default.
- W2894565839 cites W1964551504 @default.
- W2894565839 cites W1993697405 @default.
- W2894565839 cites W1995924159 @default.
- W2894565839 cites W1998428482 @default.
- W2894565839 cites W2018508409 @default.
- W2894565839 cites W2025701523 @default.
- W2894565839 cites W2027911088 @default.
- W2894565839 cites W2029738070 @default.
- W2894565839 cites W2036596008 @default.
- W2894565839 cites W2067477145 @default.
- W2894565839 cites W2068612391 @default.
- W2894565839 cites W2082357164 @default.
- W2894565839 cites W2095415260 @default.
- W2894565839 cites W2101613981 @default.
- W2894565839 cites W2119410664 @default.
- W2894565839 cites W2123059506 @default.
- W2894565839 cites W2138933797 @default.
- W2894565839 cites W2139818499 @default.
- W2894565839 cites W2140220793 @default.
- W2894565839 cites W2153312323 @default.
- W2894565839 cites W2156382695 @default.
- W2894565839 cites W2157577107 @default.
- W2894565839 cites W2162427999 @default.
- W2894565839 cites W2165707370 @default.
- W2894565839 cites W2165829657 @default.
- W2894565839 cites W2167156367 @default.
- W2894565839 cites W2197504776 @default.
- W2894565839 cites W2285304733 @default.
- W2894565839 cites W2287934955 @default.
- W2894565839 cites W2342024658 @default.
- W2894565839 cites W2419696714 @default.
- W2894565839 cites W2588657365 @default.
- W2894565839 cites W653325494 @default.
- W2894565839 doi "https://doi.org/10.1002/ddr.21458" @default.
- W2894565839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291767" @default.
- W2894565839 hasPublicationYear "2018" @default.
- W2894565839 type Work @default.
- W2894565839 sameAs 2894565839 @default.
- W2894565839 citedByCount "4" @default.
- W2894565839 countsByYear W28945658392020 @default.
- W2894565839 countsByYear W28945658392021 @default.
- W2894565839 countsByYear W28945658392022 @default.
- W2894565839 countsByYear W28945658392023 @default.
- W2894565839 crossrefType "journal-article" @default.
- W2894565839 hasAuthorship W2894565839A5000109801 @default.
- W2894565839 hasAuthorship W2894565839A5014641314 @default.
- W2894565839 hasAuthorship W2894565839A5016891523 @default.
- W2894565839 hasAuthorship W2894565839A5041106147 @default.
- W2894565839 hasAuthorship W2894565839A5044024787 @default.
- W2894565839 hasAuthorship W2894565839A5049323293 @default.
- W2894565839 hasAuthorship W2894565839A5053717079 @default.
- W2894565839 hasAuthorship W2894565839A5064198618 @default.
- W2894565839 hasAuthorship W2894565839A5064778974 @default.
- W2894565839 hasAuthorship W2894565839A5076736155 @default.
- W2894565839 hasAuthorship W2894565839A5085371439 @default.
- W2894565839 hasConcept C118687296 @default.
- W2894565839 hasConcept C185592680 @default.
- W2894565839 hasConcept C18903297 @default.
- W2894565839 hasConcept C21951064 @default.
- W2894565839 hasConcept C2776597398 @default.
- W2894565839 hasConcept C2777637488 @default.
- W2894565839 hasConcept C2781427627 @default.
- W2894565839 hasConcept C4937899 @default.
- W2894565839 hasConcept C519536355 @default.
- W2894565839 hasConcept C523546767 @default.
- W2894565839 hasConcept C54355233 @default.
- W2894565839 hasConcept C55493867 @default.
- W2894565839 hasConcept C58123911 @default.
- W2894565839 hasConcept C86803240 @default.
- W2894565839 hasConcept C89423630 @default.
- W2894565839 hasConceptScore W2894565839C118687296 @default.
- W2894565839 hasConceptScore W2894565839C185592680 @default.
- W2894565839 hasConceptScore W2894565839C18903297 @default.
- W2894565839 hasConceptScore W2894565839C21951064 @default.
- W2894565839 hasConceptScore W2894565839C2776597398 @default.
- W2894565839 hasConceptScore W2894565839C2777637488 @default.
- W2894565839 hasConceptScore W2894565839C2781427627 @default.
- W2894565839 hasConceptScore W2894565839C4937899 @default.
- W2894565839 hasConceptScore W2894565839C519536355 @default.
- W2894565839 hasConceptScore W2894565839C523546767 @default.
- W2894565839 hasConceptScore W2894565839C54355233 @default.