FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894570760> ?p ?o ?g. }

• W2894570760 abstract "Distinguishing between meaningful and meaningless sensory information is fundamental to forming accurate representations of the world. Dopamine is thought to play a central role in processing the meaningful information content of observations, which motivates an agent to update their beliefs about the environment. However, direct evidence for dopamine's role in human belief updating is lacking. We addressed this question in healthy volunteers who performed a model-based fMRI task designed to separate the neural processing of meaningful and meaningless sensory information. We modeled participant behavior using a normative Bayesian observer model and used the magnitude of the model-derived belief update following an observation to quantify its meaningful information content. We also acquired PET imaging measures of dopamine function in the same subjects. We show that the magnitude of belief updates about task structure (meaningful information), but not pure sensory surprise (meaningless information), are encoded in midbrain and ventral striatum activity. Using PET we show that the neural encoding of meaningful information is negatively related to dopamine-2/3 receptor availability in the midbrain and dexamphetamine-induced dopamine release capacity in the striatum. Trial-by-trial analysis of task performance indicated that subclinical paranoid ideation is negatively related to behavioral sensitivity to observations carrying meaningful information about the task structure. The findings provide direct evidence implicating dopamine in model-based belief updating in humans and have implications for understating the pathophysiology of psychotic disorders where dopamine function is disrupted." @default.
• W2894570760 created "2018-10-12" @default.
• W2894570760 creator A5000294737 @default.
• W2894570760 creator A5001601365 @default.
• W2894570760 creator A5011377871 @default.
• W2894570760 creator A5026197656 @default.
• W2894570760 creator A5039656642 @default.
• W2894570760 creator A5069665617 @default.
• W2894570760 creator A5073964938 @default.
• W2894570760 creator A5076672215 @default.
• W2894570760 creator A5087675404 @default.
• W2894570760 date "2018-10-08" @default.
• W2894570760 modified "2023-09-29" @default.
• W2894570760 title "Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia" @default.
• W2894570760 cites W1598372418 @default.
• W2894570760 cites W1605722113 @default.
• W2894570760 cites W1839259206 @default.
• W2894570760 cites W1872057083 @default.
• W2894570760 cites W1972738529 @default.
• W2894570760 cites W1982900708 @default.
• W2894570760 cites W1987223490 @default.
• W2894570760 cites W1991528023 @default.
• W2894570760 cites W2007294293 @default.
• W2894570760 cites W2007414406 @default.
• W2894570760 cites W2009429333 @default.
• W2894570760 cites W2016202155 @default.
• W2894570760 cites W2017709022 @default.
• W2894570760 cites W2020682620 @default.
• W2894570760 cites W2024973096 @default.
• W2894570760 cites W2035658250 @default.
• W2894570760 cites W2038018468 @default.
• W2894570760 cites W2039546655 @default.
• W2894570760 cites W2041219933 @default.
• W2894570760 cites W2050029064 @default.
• W2894570760 cites W2053759320 @default.
• W2894570760 cites W2059763388 @default.
• W2894570760 cites W2079908656 @default.
• W2894570760 cites W2085215023 @default.
• W2894570760 cites W2085754318 @default.
• W2894570760 cites W2090592015 @default.
• W2894570760 cites W2094134651 @default.
• W2894570760 cites W2098613458 @default.
• W2894570760 cites W2100040139 @default.
• W2894570760 cites W2100376975 @default.
• W2894570760 cites W2102305988 @default.
• W2894570760 cites W2102803424 @default.
• W2894570760 cites W2110000143 @default.
• W2894570760 cites W2117671988 @default.
• W2894570760 cites W2117726420 @default.
• W2894570760 cites W2120310131 @default.
• W2894570760 cites W2121007598 @default.
• W2894570760 cites W2123429050 @default.
• W2894570760 cites W2126680030 @default.
• W2894570760 cites W2128918015 @default.
• W2894570760 cites W2131622291 @default.
• W2894570760 cites W2134305330 @default.
• W2894570760 cites W2135609128 @default.
• W2894570760 cites W2140487181 @default.
• W2894570760 cites W2144534164 @default.
• W2894570760 cites W2149565728 @default.
• W2894570760 cites W2160695817 @default.
• W2894570760 cites W2161689902 @default.
• W2894570760 cites W2163456594 @default.
• W2894570760 cites W2165298640 @default.
• W2894570760 cites W2167125619 @default.
• W2894570760 cites W2191449095 @default.
• W2894570760 cites W2197227940 @default.
• W2894570760 cites W2210805002 @default.
• W2894570760 cites W2211680833 @default.
• W2894570760 cites W2253007843 @default.
• W2894570760 cites W2271599771 @default.
• W2894570760 cites W2288411222 @default.
• W2894570760 cites W2325226536 @default.
• W2894570760 cites W2375881150 @default.
• W2894570760 cites W2411013142 @default.
• W2894570760 cites W2411519439 @default.
• W2894570760 cites W2466227311 @default.
• W2894570760 cites W2509180953 @default.
• W2894570760 cites W2528560335 @default.
• W2894570760 cites W2546497559 @default.
• W2894570760 cites W2555795336 @default.
• W2894570760 cites W2561598420 @default.
• W2894570760 cites W2604220916 @default.
• W2894570760 cites W2742165752 @default.
• W2894570760 cites W2754726085 @default.
• W2894570760 cites W2766827141 @default.
• W2894570760 cites W2797393690 @default.
• W2894570760 cites W2800881127 @default.
• W2894570760 cites W2801251491 @default.
• W2894570760 cites W2883690703 @default.
• W2894570760 cites W2887111375 @default.
• W2894570760 cites W2951066214 @default.
• W2894570760 cites W2951785195 @default.
• W2894570760 cites W2953170694 @default.
• W2894570760 cites W4241694975 @default.
• W2894570760 cites W821630811 @default.
• W2894570760 doi "https://doi.org/10.1073/pnas.1809298115" @default.
• W2894570760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205436" @default.
• W2894570760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30297411" @default.
• W2894570760 hasPublicationYear "2018" @default.

• next