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- W2894571190 abstract "Introduction: According to the BCLC staging, advanced hepatocellular carcinoma (HCC) could be determined only if performance status (PS) is 1∼2, which was not recommended performing hepatectomy. In the real clinical practice, however, PS is not a key indicator of hepatectomy for HCC. We aimed to investigate the impact of PS on recurrence and survival after HCC resection. Methods: Multicenter data of 1,531 Chinese patients undergoing liver resection of HCC between 2005 and 2015 were retrospectively analyzed. They were divided into PS 0 group and PS 1 group. Perioperative mortality and morbidity, overall survival (OS) and recurrence-free survival (RFS) were compared, and multivariable Cox-regression analyses of OS and RFS were performed. Results: The perioperative mortality and major morbidity rates of PS 0 and 1 patients were similar (P = 0.875 and 0.235, respectively). The median OS and RFS of PS 1 patients were significantly poorer than PS 0 patients (both P < 0.001). Multivariable analyses revealed that PS 1 was independent risk factors of OS (HR: 1.301, P < 0.001) and RFS (HR: 1.420, P = 0.007). In the subgroup analysis, the OS and RFS of PS 1 patients without vascular invasion (VI)/extrahepatic metastasis (ES) were significantly better than PS 1 patients with VI/ES. Conclusions: Liver resection of HCC for PS 1 patients was as safe as for PS 0 patients. Although PS 1 was an independent risk factor of recurrence and survival, the prognosis after liver resection was still acceptable, especially when without VI/ES." @default.
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- W2894571190 date "2018-09-01" @default.
- W2894571190 modified "2023-09-27" @default.
- W2894571190 title "Impact of performance status on recurrence and survival after liver resection for patients with hepatocellular carcinoma: A Chinese Multicenter Study" @default.
- W2894571190 doi "https://doi.org/10.1016/j.hpb.2018.06.2755" @default.
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