Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894571922> ?p ?o ?g. }
- W2894571922 endingPage "764" @default.
- W2894571922 startingPage "755" @default.
- W2894571922 abstract "Introduction: Chymase is primarily found in mast cells (MCs), fibroblasts, and vascular endothelial cells. MC chymase is released into the extracellular interstitium in response to inflammatory signals, tissue injury, and cellular stress. Among many functions, chymase is a major extravascular source for angiotensin II (Ang II) generation. Several recent pre-clinical and a few clinical studies point to the relatively unrecognized fact that chymase inhibition may have significant therapeutic advantages over other treatments in halting progression of cardiac and vascular disease.Area covered: The present review covers patent literature on chymase inhibitors for the treatment of cardiac diseases registered between 2010 and 2018.Expert opinion: Increase in cardiac MC number in various cardiac diseases has been found in pathological tissues of human and experimental animals. Meta-analysis data from large clinical trials employing angiotensin-converting enzyme (ACE) inhibitors show a relatively small risk reduction of clinical cardiovascular endpoints. The disconnect between the expected benefit associated with Ang II blockade of synthesis or activity underscores a greater participation of chymase compared to ACE in forming Ang II in humans. Emerging literature and a reconsideration of previous studies provide lucid arguments to reconsider chymase as a primary Ang II forming enzyme in human heart and vasculature." @default.
- W2894571922 created "2018-10-12" @default.
- W2894571922 creator A5014633095 @default.
- W2894571922 creator A5088391372 @default.
- W2894571922 date "2018-10-10" @default.
- W2894571922 modified "2023-10-14" @default.
- W2894571922 title "Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010–2018)" @default.
- W2894571922 cites W1025095975 @default.
- W2894571922 cites W1521804991 @default.
- W2894571922 cites W1586885249 @default.
- W2894571922 cites W1600920155 @default.
- W2894571922 cites W1603013239 @default.
- W2894571922 cites W1719241967 @default.
- W2894571922 cites W1869662690 @default.
- W2894571922 cites W1951349994 @default.
- W2894571922 cites W1965919729 @default.
- W2894571922 cites W1971896300 @default.
- W2894571922 cites W1972557917 @default.
- W2894571922 cites W1973135001 @default.
- W2894571922 cites W1973602059 @default.
- W2894571922 cites W1977621394 @default.
- W2894571922 cites W1984268475 @default.
- W2894571922 cites W1988066388 @default.
- W2894571922 cites W1993305093 @default.
- W2894571922 cites W1995175728 @default.
- W2894571922 cites W1995676104 @default.
- W2894571922 cites W1998118058 @default.
- W2894571922 cites W1999107098 @default.
- W2894571922 cites W2004857614 @default.
- W2894571922 cites W2007796515 @default.
- W2894571922 cites W2007836497 @default.
- W2894571922 cites W2010832543 @default.
- W2894571922 cites W2016474439 @default.
- W2894571922 cites W2016511436 @default.
- W2894571922 cites W2017420261 @default.
- W2894571922 cites W2020553724 @default.
- W2894571922 cites W2020675129 @default.
- W2894571922 cites W2021469752 @default.
- W2894571922 cites W2023531166 @default.
- W2894571922 cites W2025672718 @default.
- W2894571922 cites W2026793582 @default.
- W2894571922 cites W2027309030 @default.
- W2894571922 cites W2027569634 @default.
- W2894571922 cites W2028032945 @default.
- W2894571922 cites W2030538756 @default.
- W2894571922 cites W2034700253 @default.
- W2894571922 cites W2035405956 @default.
- W2894571922 cites W2037791377 @default.
- W2894571922 cites W2040684561 @default.
- W2894571922 cites W2041718175 @default.
- W2894571922 cites W2043795855 @default.
- W2894571922 cites W2047699084 @default.
- W2894571922 cites W2048138796 @default.
- W2894571922 cites W2049386378 @default.
- W2894571922 cites W2049423444 @default.
- W2894571922 cites W2050050383 @default.
- W2894571922 cites W2053071530 @default.
- W2894571922 cites W2054815702 @default.
- W2894571922 cites W2060164475 @default.
- W2894571922 cites W2060383269 @default.
- W2894571922 cites W2061988509 @default.
- W2894571922 cites W2065533272 @default.
- W2894571922 cites W2065625486 @default.
- W2894571922 cites W2066564971 @default.
- W2894571922 cites W2066779636 @default.
- W2894571922 cites W2068896738 @default.
- W2894571922 cites W2072603225 @default.
- W2894571922 cites W2075056638 @default.
- W2894571922 cites W2076910254 @default.
- W2894571922 cites W2078033101 @default.
- W2894571922 cites W2080670526 @default.
- W2894571922 cites W2081124060 @default.
- W2894571922 cites W2081234813 @default.
- W2894571922 cites W2086658900 @default.
- W2894571922 cites W2100102193 @default.
- W2894571922 cites W2100135568 @default.
- W2894571922 cites W2101567381 @default.
- W2894571922 cites W2102027213 @default.
- W2894571922 cites W2103092861 @default.
- W2894571922 cites W2110508933 @default.
- W2894571922 cites W2111256272 @default.
- W2894571922 cites W2113755614 @default.
- W2894571922 cites W2125086507 @default.
- W2894571922 cites W2133252500 @default.
- W2894571922 cites W2139124675 @default.
- W2894571922 cites W2143760645 @default.
- W2894571922 cites W2153090578 @default.
- W2894571922 cites W2154286360 @default.
- W2894571922 cites W2161697359 @default.
- W2894571922 cites W2171083892 @default.
- W2894571922 cites W2172073611 @default.
- W2894571922 cites W2212747205 @default.
- W2894571922 cites W2251421794 @default.
- W2894571922 cites W2252644669 @default.
- W2894571922 cites W2301823872 @default.
- W2894571922 cites W2405032938 @default.
- W2894571922 cites W2407363715 @default.
- W2894571922 cites W2410011135 @default.