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- W2894572705 abstract "Introduction: Two-stage hepatectomy is a potentially curative treatment for initially unresectable bilobar colorectal liver metastases. Only retrospective studies have been published with various survival rates and drop-out rates between the stages. Methods: We previously conducted a prospective randomized study to assess the efficacy of hyaluronic acid membranes to prevent adhesions between the two stages between 2008 and 2010. We analysed the data of the patients included in this study as a single cohort of patients to evaluate the oncological outcomes of two-stage hepatectomies. Survival data are reported from the date of the first liver surgery. Results: Among the 54 patients randomized at the end of the first hepatectomy, 41 had both liver stages (drop-out rate of 24%). In intent-to-treat analysis (n=54), 4-year overall survival (OS) was 50% (CI95%: 36-62) and median progression-free survival (PFS) was 12.5 months. In patients who completed both stages (n=41), 4-year OS was 59% (CI95%: 42-72). In patients who failed to have the second hepatectomy, 2-year OS was 38.5% (CI95%: 14-62). Except for completion of both stages, no prognostic factors were found in multivariate analysis. Conclusion: In intent-to-treat analysis, patients candidates to two-stage hepatectomy achieve comparable oncological outcomes than those with resectable metastases. Prognostic of patients who failed the complete strategy had better prognostic than expected." @default.
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- W2894572705 date "2018-09-01" @default.
- W2894572705 modified "2023-10-17" @default.
- W2894572705 title "Long-term oncological outcomes of two-stage hepatectomy for unresectable colorectal liver metastases: results of a prospective study" @default.
- W2894572705 doi "https://doi.org/10.1016/j.hpb.2018.06.2627" @default.
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