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• W2894575434 startingPage "48" @default.
• W2894575434 abstract "Abstract Herein, we have reported three novel mononuclear copper (II) complexes 1 [Cu(L1)2], 2 [Cu(L2)2] and 3 [Cu(L3)2] where, L1H = (2-(4-methylbenzylimino)methyl)-4-nitrophenol, C15H14N2O3)), L2H = (2-(4-methylbenzylimino)methyl)-4-chlorophenol, C15H14ClNO)) and L3H = (2-(4-methylbenzylimino)methyl)-4,6-dichlorophenol, C15H13Cl2NO)) have been characterized by several physicochemical techniques. Having a base of spectroscopic and analytical data, complexes 1, 2 and 3 exhibited square planar geometry where Schiff bases act as bi-dentate NO donar ligands. DNA biding and nuclease activity studies against CT-DNA and supercoiled pBR322-DNA respectively revealed an intercalative mode of binding and also cleave efficient manner. Moreover, synthesized compounds were investigated for their in-vitro cytotoxic potential against human breast cancer cell (MCF-7) and oral cancer cell (KB3) using cis-platin as standard drug under MTT assay, results revealed that the biological potency of synthesized compounds as well as antibacterial activity." @default.
• W2894575434 created "2018-10-12" @default.
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• W2894575434 date "2018-12-01" @default.
• W2894575434 modified "2023-09-25" @default.
• W2894575434 title "Three mononuclear Cu (II) complexes based on p-tolylmethanamine Schiff bases: In-vitro cytotoxicity, DNA binding ability, nuclease activity and antibacterial studies" @default.
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• W2894575434 doi "https://doi.org/10.1016/j.inoche.2018.09.033" @default.
• W2894575434 hasPublicationYear "2018" @default.
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