FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894576283> ?p ?o ?g. }

• W2894576283 endingPage "226" @default.
• W2894576283 startingPage "220" @default.
• W2894576283 abstract "In certain vertebrate species, the developing embryo breaks left-right symmetry in a transient organising structure: the Left-Right Organiser (LRO) known as the node in mice, and Kupffer's vesicle in fish. Directional cilia-driven flow is integral to this symmetry-breaking process, however the mechanism by which this flow is translated into an asymmetric signal remains contested; the principal theories are either flow transport of vesicles containing morphogens, or flow mechanosensing by cilia. Whilst some recent work favours the morphogen theory, other findings seem to support mechanosensing. In this study, we consider a hypothesis whereby the cilia themselves drive the release of morphogen-carrying extracellular vesicles (EVs) into the LRO; namely, that fluid stresses on the cell membrane induce/enhance exocytosis of EVs. Using a mathematical model, we calculate significant wall normal and shear stresses for a range of typical cilium parameter values comparable to levels capable of enhancing exocytosis. This mechanism may be able to reconcile the apparently conflicting experimental evidence." @default.
• W2894576283 created "2018-10-12" @default.
• W2894576283 creator A5007916494 @default.
• W2894576283 creator A5034472995 @default.
• W2894576283 creator A5055464225 @default.
• W2894576283 creator A5072391540 @default.
• W2894576283 date "2019-01-01" @default.
• W2894576283 modified "2023-09-24" @default.
• W2894576283 title "Wall stress enhanced exocytosis of extracellular vesicles as a possible mechanism of left-right symmetry-breaking in vertebrate development" @default.
• W2894576283 cites W1927459862 @default.
• W2894576283 cites W1967546149 @default.
• W2894576283 cites W1969212379 @default.
• W2894576283 cites W1983201013 @default.
• W2894576283 cites W2003103160 @default.
• W2894576283 cites W2011983184 @default.
• W2894576283 cites W2029279705 @default.
• W2894576283 cites W2030062022 @default.
• W2894576283 cites W2046292375 @default.
• W2894576283 cites W2049365982 @default.
• W2894576283 cites W2056451246 @default.
• W2894576283 cites W2063376024 @default.
• W2894576283 cites W2081431336 @default.
• W2894576283 cites W2083904901 @default.
• W2894576283 cites W2107494663 @default.
• W2894576283 cites W2114075637 @default.
• W2894576283 cites W2117107511 @default.
• W2894576283 cites W2122596916 @default.
• W2894576283 cites W2136800614 @default.
• W2894576283 cites W2184633894 @default.
• W2894576283 cites W2261520463 @default.
• W2894576283 cites W2305650242 @default.
• W2894576283 cites W2311871350 @default.
• W2894576283 cites W2592804294 @default.
• W2894576283 cites W2625599949 @default.
• W2894576283 cites W2752837578 @default.
• W2894576283 cites W2805817882 @default.
• W2894576283 cites W2885800130 @default.
• W2894576283 cites W4239173138 @default.
• W2894576283 doi "https://doi.org/10.1016/j.jtbi.2018.10.015" @default.
• W2894576283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300649" @default.
• W2894576283 hasPublicationYear "2019" @default.
• W2894576283 type Work @default.
• W2894576283 sameAs 2894576283 @default.
• W2894576283 citedByCount "8" @default.
• W2894576283 countsByYear W28945762832019 @default.
• W2894576283 countsByYear W28945762832020 @default.
• W2894576283 countsByYear W28945762832022 @default.
• W2894576283 crossrefType "journal-article" @default.
• W2894576283 hasAuthorship W2894576283A5007916494 @default.
• W2894576283 hasAuthorship W2894576283A5034472995 @default.
• W2894576283 hasAuthorship W2894576283A5055464225 @default.
• W2894576283 hasAuthorship W2894576283A5072391540 @default.
• W2894576283 hasBestOaLocation W28945762832 @default.
• W2894576283 hasConcept C100094513 @default.
• W2894576283 hasConcept C104317684 @default.
• W2894576283 hasConcept C105702510 @default.
• W2894576283 hasConcept C121332964 @default.
• W2894576283 hasConcept C12554922 @default.
• W2894576283 hasConcept C130316041 @default.
• W2894576283 hasConcept C175969161 @default.
• W2894576283 hasConcept C204795200 @default.
• W2894576283 hasConcept C2778386714 @default.
• W2894576283 hasConcept C2910722709 @default.
• W2894576283 hasConcept C41625074 @default.
• W2894576283 hasConcept C54355233 @default.
• W2894576283 hasConcept C55493867 @default.
• W2894576283 hasConcept C57879066 @default.
• W2894576283 hasConcept C62520636 @default.
• W2894576283 hasConcept C86803240 @default.
• W2894576283 hasConcept C89611455 @default.
• W2894576283 hasConcept C95444343 @default.
• W2894576283 hasConceptScore W2894576283C100094513 @default.
• W2894576283 hasConceptScore W2894576283C104317684 @default.
• W2894576283 hasConceptScore W2894576283C105702510 @default.
• W2894576283 hasConceptScore W2894576283C121332964 @default.
• W2894576283 hasConceptScore W2894576283C12554922 @default.
• W2894576283 hasConceptScore W2894576283C130316041 @default.
• W2894576283 hasConceptScore W2894576283C175969161 @default.
• W2894576283 hasConceptScore W2894576283C204795200 @default.
• W2894576283 hasConceptScore W2894576283C2778386714 @default.
• W2894576283 hasConceptScore W2894576283C2910722709 @default.
• W2894576283 hasConceptScore W2894576283C41625074 @default.
• W2894576283 hasConceptScore W2894576283C54355233 @default.
• W2894576283 hasConceptScore W2894576283C55493867 @default.
• W2894576283 hasConceptScore W2894576283C57879066 @default.
• W2894576283 hasConceptScore W2894576283C62520636 @default.
• W2894576283 hasConceptScore W2894576283C86803240 @default.
• W2894576283 hasConceptScore W2894576283C89611455 @default.
• W2894576283 hasConceptScore W2894576283C95444343 @default.
• W2894576283 hasFunder F4320334627 @default.
• W2894576283 hasLocation W28945762831 @default.
• W2894576283 hasLocation W28945762832 @default.
• W2894576283 hasLocation W28945762833 @default.
• W2894576283 hasOpenAccess W2894576283 @default.
• W2894576283 hasPrimaryLocation W28945762831 @default.
• W2894576283 hasRelatedWork W1493571954 @default.
• W2894576283 hasRelatedWork W2100275096 @default.
• W2894576283 hasRelatedWork W2140295200 @default.

• next