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• W2894576934 abstract "CONCLUSIONS:Organophosphorous poisoning is most prevalent in the 21-30 age group. Incidence is more common in males.• Organophosphorous poisoning is more common among agricultural labourers and unskilled workers.• The most important cause for consumption of organophosphorous poison is self harm.• The common route of exposure is ingestion of poison and it is associated with clinical severity.• The quantity consumed has direct proportional relationship with severity of poisoning.• The duration of stay in the hospital has significant correlation with clinical severity.• The higher the clinical grade of poisoning at initial presentation more the need of ventilatory support and adverse the outcome.• The following parameters predict the need of ventilatory support, grade 3 clinical severity, proximal muscle affection, low values of day 1 serum cholinesterase.• Ingestion of OPCs produced abnormalities in Nerve Conduction Studies in the form of axonopathy, sensory neuropathy and demyelination.• Ingestion of Monocrotophos produced death in three patients and neuropathy in remaining patients.• Ingestion of Dimethoate produced all the three abnormalities in NCS.• Ingestion of Monocrotophos caused axonopathy and sensory neuropathy.SUMMARY:Organophosphorous poisoning is a menace to the human race both as aweapon of mass destruction and a misused pesticide of self harm. The casefatality rate exceeds 60% in developing countries where there are many pit fallsin treatment protocol and research activities. So a comprehensive analysis of 29patients of organophosphorous poisoning was done in Poison Centre,Government General hospital Chennai.All the cases included in the studied underwent detailed clinicalevaluation, extensive laboratory work up and nerve conduction studies. Eachpatient was monitored periodically till the outcome. There were 24 males and5 female patients. The predominant age group was 21- 30years. 28 patientswere suicide attempts and 1 had accidental exposure. 27 of the patients werepoisoned through the gastrointestinal route. One patient had inhalationalpoisoning and one patient had topical exposure. There were 9 different types ofOP insecticide agents involved. According to Dreisbach clinical criteria atadmission, all patients belong to the severe grade of poisoning. Serumcholinesterase levels had significant correlation with clinical severity,mechanical ventilation and outcome.Nerve conduction studies were done on the third or fourth week ofhospital stay. Both upper and lower limb nerves were studied. Thirteenpatients had evidence of OPIDP. Three patients had evidence of significantaxonopathy, 6 patients had evidence of demyelination and 8 patients had evidence of sensory neuropathy." @default.
• W2894576934 created "2018-10-12" @default.
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• W2894576934 date "2009-03-01" @default.
• W2894576934 modified "2023-09-27" @default.
• W2894576934 title "Study on Nerve Conduction Abnormalities in Organo Phosphorus Poisoning" @default.
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