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• W2894577108 abstract "<b><i>Objective:</i></b> To evaluate the possible influence of electrode trajectories penetrating the caudate nucleus (CN) on cognitive outcomes in deep brain stimulation (DBS) surgery for Parkinson’s disease (PD). <b><i>Background:</i></b> It is currently unclear how mandatory CN avoidance during trajectory planning is. <b><i>Design/Methods:</i></b> Electrode trajectories were determined to be inside, outside, or in border region of the CN. Pre- and postoperative neuropsychological tests of each trajectory group were compared in order to evaluate possible differences in cognitive outcomes 12 months after bilateral STN DBS. <b><i>Results:</i></b> One hundred six electrode tracks in 53 patients were evaluated. Bilateral penetration of the CN occurred in 15 (28%) patients, while unilateral penetration occurred in 28 (53%). In 19 (36%) patients tracks were located in the border region of the CN. There was no electrode penetration of the CN in 10 (19%) patients. No difference in cognitive outcomes was found between the different groups. <b><i>Conclusion:</i></b> Cognitive outcome was not influenced by DBS electrode tracks penetrating the CN. It is both feasible and sensible to avoid electrode tracks through the CN when possible, considering its function and anatomical position. However, penetration of the CN can be considered without major concerns regarding cognitive decline when this facilitates optimal trajectory planning due to specific individual anatomical variations." @default.
• W2894577108 created "2018-10-12" @default.
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• W2894577108 date "2018-01-01" @default.
• W2894577108 modified "2023-09-27" @default.
• W2894577108 title "Electrode Penetration of the Caudate Nucleus in Deep Brain Stimulation Surgery for Parkinson’s Disease" @default.
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• W2894577108 doi "https://doi.org/10.1159/000489944" @default.
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