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- W2894577257 abstract "Protein-based macromolecules such as keratin, silk fibroin, collagen, gelatin, and fibrin have emerged as potential candidate materials with unique structural and functional characteristics. Despite many advantages, the development of tissue-engineered constructs that can match the biological context of real tissue matrix remains a challenge in tissue engineering (TE). The tissue-engineered constructs should also support vascularization. Protein-based macromolecules, in pristine or combine form, provide a promising platform to engineer constructs with unique design and functionalities which are highly essential for an appropriate stimulation and differentiation of cells in a specific TE approach. However, much work remains to be undertaken with particular reference to in-depth interactions between constructed cues and target host tissues. Thus, modern advancements are emphasizing to understand critiques and functionalization of protein-based macromolecule that organize not only cellular activities but also tissue regenerations. In this review, numerous physicochemical, functional, and structural characteristics of protein-based macromolecules such as keratin, silk fibroin, collagen, gelatin, and fibrin are discussed. This review also presents the hope vs. hype phenomenon for tissue engineering. Later part of the review focuses on different requisite characteristics and their role in TE. The discussion presented here could prove highly useful for the construction of scaffolds with requisite features." @default.
- W2894577257 created "2018-10-12" @default.
- W2894577257 creator A5002753319 @default.
- W2894577257 creator A5033640002 @default.
- W2894577257 creator A5043578051 @default.
- W2894577257 creator A5054661021 @default.
- W2894577257 creator A5058890496 @default.
- W2894577257 creator A5075426877 @default.
- W2894577257 date "2019-01-01" @default.
- W2894577257 modified "2023-10-03" @default.
- W2894577257 title "Physiochemical characteristics and bone/cartilage tissue engineering potentialities of protein-based macromolecules — A review" @default.
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