FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894577668> ?p ?o ?g. }

• W2894577668 endingPage "397" @default.
• W2894577668 startingPage "390" @default.
• W2894577668 abstract "Alginate is one of the main extracellular polymeric substances (EPS) in biofilms of Cystic Fibrosis (CF) patients suffering from pulmonary infections. Gentamicin sulfate (GS) can strongly bind to alginate resulting in loss of pharmacological activity; however neither the mechanism nor its repercussion is fully understood. In this study, we investigated how GS modifies the alginate macromolecular network and its microenvironment.Alginate gels of two different compositions (either enriched in guluronate units (G) or enriched in mannuronate units (M)) were crosslinked with Ca2+ and exposed to GS at varying times and concentrations. The complexes formed were characterized via turbidimetry, mechanical tests, swelling assay, calorimetry techniques, nuclear magnetic resonance, Ca2+ displacement, macromolecular probe diffusion and pH alteration.In presence of GS, the alginate network and its environment undergo a tremendous reorganization in terms of gel density, stiffness, diffusion property, presence and state of the water molecules. We noted that the intensity of those alterations is directly dependent on the polysaccharide motif composition (ratio M/G).Our results underline the importance of alginate as biofilm component, its pernicious role during antibiotherapy and could represent a potential macromolecular target to improve anti-infectious therapies." @default.
• W2894577668 created "2018-10-12" @default.
• W2894577668 creator A5024470477 @default.
• W2894577668 creator A5048836772 @default.
• W2894577668 creator A5055489989 @default.
• W2894577668 creator A5067053588 @default.
• W2894577668 creator A5073915256 @default.
• W2894577668 creator A5080521089 @default.
• W2894577668 creator A5081946074 @default.
• W2894577668 creator A5088124093 @default.
• W2894577668 date "2019-01-01" @default.
• W2894577668 modified "2023-09-26" @default.
• W2894577668 title "Interaction of gentamicin sulfate with alginate and consequences on the physico-chemical properties of alginate-containing biofilms" @default.
• W2894577668 cites W1901233028 @default.
• W2894577668 cites W1971500643 @default.
• W2894577668 cites W1975807938 @default.
• W2894577668 cites W1984994955 @default.
• W2894577668 cites W2002102245 @default.
• W2894577668 cites W2005628229 @default.
• W2894577668 cites W2017255842 @default.
• W2894577668 cites W2023028948 @default.
• W2894577668 cites W2050967538 @default.
• W2894577668 cites W2055073693 @default.
• W2894577668 cites W2057985892 @default.
• W2894577668 cites W2066703675 @default.
• W2894577668 cites W2067044076 @default.
• W2894577668 cites W2085320887 @default.
• W2894577668 cites W2090601537 @default.
• W2894577668 cites W2098917703 @default.
• W2894577668 cites W2101425232 @default.
• W2894577668 cites W2101830519 @default.
• W2894577668 cites W2103615189 @default.
• W2894577668 cites W2121941457 @default.
• W2894577668 cites W2127778188 @default.
• W2894577668 cites W2128480720 @default.
• W2894577668 cites W2132871872 @default.
• W2894577668 cites W2149908911 @default.
• W2894577668 cites W2163416143 @default.
• W2894577668 cites W2166083475 @default.
• W2894577668 cites W2168099251 @default.
• W2894577668 cites W2168429016 @default.
• W2894577668 cites W2169314851 @default.
• W2894577668 cites W2178682063 @default.
• W2894577668 cites W2179722594 @default.
• W2894577668 cites W2253068377 @default.
• W2894577668 cites W2515096969 @default.
• W2894577668 cites W2545974513 @default.
• W2894577668 cites W2593571691 @default.
• W2894577668 cites W2766744214 @default.
• W2894577668 cites W2783595944 @default.
• W2894577668 doi "https://doi.org/10.1016/j.ijbiomac.2018.10.025" @default.
• W2894577668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30304700" @default.
• W2894577668 hasPublicationYear "2019" @default.
• W2894577668 type Work @default.
• W2894577668 sameAs 2894577668 @default.
• W2894577668 citedByCount "11" @default.
• W2894577668 countsByYear W28945776682019 @default.
• W2894577668 countsByYear W28945776682020 @default.
• W2894577668 countsByYear W28945776682021 @default.
• W2894577668 countsByYear W28945776682022 @default.
• W2894577668 countsByYear W28945776682023 @default.
• W2894577668 crossrefType "journal-article" @default.
• W2894577668 hasAuthorship W2894577668A5024470477 @default.
• W2894577668 hasAuthorship W2894577668A5048836772 @default.
• W2894577668 hasAuthorship W2894577668A5055489989 @default.
• W2894577668 hasAuthorship W2894577668A5067053588 @default.
• W2894577668 hasAuthorship W2894577668A5073915256 @default.
• W2894577668 hasAuthorship W2894577668A5080521089 @default.
• W2894577668 hasAuthorship W2894577668A5081946074 @default.
• W2894577668 hasAuthorship W2894577668A5088124093 @default.
• W2894577668 hasBestOaLocation W28945776682 @default.
• W2894577668 hasConcept C100817775 @default.
• W2894577668 hasConcept C12554922 @default.
• W2894577668 hasConcept C127413603 @default.
• W2894577668 hasConcept C129968341 @default.
• W2894577668 hasConcept C185592680 @default.
• W2894577668 hasConcept C204389451 @default.
• W2894577668 hasConcept C2775832221 @default.
• W2894577668 hasConcept C2776648616 @default.
• W2894577668 hasConcept C2780777798 @default.
• W2894577668 hasConcept C2910288237 @default.
• W2894577668 hasConcept C42360764 @default.
• W2894577668 hasConcept C501593827 @default.
• W2894577668 hasConcept C523546767 @default.
• W2894577668 hasConcept C54355233 @default.
• W2894577668 hasConcept C55493867 @default.
• W2894577668 hasConcept C58123911 @default.
• W2894577668 hasConcept C86803240 @default.
• W2894577668 hasConceptScore W2894577668C100817775 @default.
• W2894577668 hasConceptScore W2894577668C12554922 @default.
• W2894577668 hasConceptScore W2894577668C127413603 @default.
• W2894577668 hasConceptScore W2894577668C129968341 @default.
• W2894577668 hasConceptScore W2894577668C185592680 @default.
• W2894577668 hasConceptScore W2894577668C204389451 @default.
• W2894577668 hasConceptScore W2894577668C2775832221 @default.
• W2894577668 hasConceptScore W2894577668C2776648616 @default.
• W2894577668 hasConceptScore W2894577668C2780777798 @default.
• W2894577668 hasConceptScore W2894577668C2910288237 @default.

• next