Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894580089> ?p ?o ?g. }
- W2894580089 abstract "Summary When migratory T cells encounter antigen presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information and are critical for T cell immunity. While the cellular processes underlying synapse formation have been well-characterized, those that maintain the symmetry, and thereby the stability of the synapse remain unknown. Here we identify an antigen-triggered mechanism that actively promotes T cell synapse symmetry by generating cytoskeletal tension in the plane of the synapse through focal nucleation of actin via Wiskott -Aldrich syndrome Protein (WASP), and contraction of the resultant actin filaments by myosin II. Following T cell activation, WASP is degraded, leading to cytoskeletal rearrangement and tension decay, which result in synapse breaking. Thus, our study identifies and characterizes a mechanical program within otherwise highly motile T cells that sustains the symmetry and stability of the T cell-APC synaptic contact." @default.
- W2894580089 created "2018-10-12" @default.
- W2894580089 creator A5000197567 @default.
- W2894580089 creator A5035163409 @default.
- W2894580089 creator A5038330886 @default.
- W2894580089 creator A5041772105 @default.
- W2894580089 creator A5046611398 @default.
- W2894580089 creator A5057562238 @default.
- W2894580089 creator A5085077288 @default.
- W2894580089 creator A5086839544 @default.
- W2894580089 creator A5087926553 @default.
- W2894580089 date "2018-10-08" @default.
- W2894580089 modified "2023-09-23" @default.
- W2894580089 title "Cytoskeletal tension actively sustains the migratory T cell synaptic contact" @default.
- W2894580089 cites W1235098512 @default.
- W2894580089 cites W1606449940 @default.
- W2894580089 cites W1753012612 @default.
- W2894580089 cites W1900620157 @default.
- W2894580089 cites W1966921573 @default.
- W2894580089 cites W1970594700 @default.
- W2894580089 cites W1972669264 @default.
- W2894580089 cites W1974494916 @default.
- W2894580089 cites W1975132186 @default.
- W2894580089 cites W1977237743 @default.
- W2894580089 cites W1979383751 @default.
- W2894580089 cites W1982536444 @default.
- W2894580089 cites W1990447767 @default.
- W2894580089 cites W1990458269 @default.
- W2894580089 cites W2012826756 @default.
- W2894580089 cites W2015776459 @default.
- W2894580089 cites W2017602598 @default.
- W2894580089 cites W2024957425 @default.
- W2894580089 cites W2030704413 @default.
- W2894580089 cites W2036071626 @default.
- W2894580089 cites W2036377994 @default.
- W2894580089 cites W2036716507 @default.
- W2894580089 cites W2047488334 @default.
- W2894580089 cites W2049398130 @default.
- W2894580089 cites W2051178853 @default.
- W2894580089 cites W2053270078 @default.
- W2894580089 cites W2057353879 @default.
- W2894580089 cites W2058301131 @default.
- W2894580089 cites W2062478481 @default.
- W2894580089 cites W2063220206 @default.
- W2894580089 cites W2064593553 @default.
- W2894580089 cites W2070638961 @default.
- W2894580089 cites W2076171916 @default.
- W2894580089 cites W2077375508 @default.
- W2894580089 cites W2077634410 @default.
- W2894580089 cites W2079595896 @default.
- W2894580089 cites W2083483039 @default.
- W2894580089 cites W2085767196 @default.
- W2894580089 cites W2088355509 @default.
- W2894580089 cites W2094476644 @default.
- W2894580089 cites W2096234619 @default.
- W2894580089 cites W2098278940 @default.
- W2894580089 cites W2098511533 @default.
- W2894580089 cites W2104960985 @default.
- W2894580089 cites W2121036696 @default.
- W2894580089 cites W2125921975 @default.
- W2894580089 cites W2126496496 @default.
- W2894580089 cites W2127424425 @default.
- W2894580089 cites W2130159724 @default.
- W2894580089 cites W2133240422 @default.
- W2894580089 cites W2136070854 @default.
- W2894580089 cites W2145069321 @default.
- W2894580089 cites W2145123926 @default.
- W2894580089 cites W2148328620 @default.
- W2894580089 cites W2149928606 @default.
- W2894580089 cites W2151083265 @default.
- W2894580089 cites W2158421588 @default.
- W2894580089 cites W2162807561 @default.
- W2894580089 cites W2163802608 @default.
- W2894580089 cites W2167243609 @default.
- W2894580089 cites W2167670122 @default.
- W2894580089 cites W2176758530 @default.
- W2894580089 cites W2239975768 @default.
- W2894580089 cites W2337069565 @default.
- W2894580089 cites W2417253274 @default.
- W2894580089 cites W2460280010 @default.
- W2894580089 cites W2514159422 @default.
- W2894580089 cites W2514175262 @default.
- W2894580089 cites W2544486379 @default.
- W2894580089 cites W2587773631 @default.
- W2894580089 cites W2760458695 @default.
- W2894580089 cites W2782425490 @default.
- W2894580089 cites W2784258676 @default.
- W2894580089 cites W2784493877 @default.
- W2894580089 cites W2784975031 @default.
- W2894580089 cites W2788577149 @default.
- W2894580089 cites W2794924150 @default.
- W2894580089 cites W2801828319 @default.
- W2894580089 cites W2803388365 @default.
- W2894580089 doi "https://doi.org/10.1101/437236" @default.
- W2894580089 hasPublicationYear "2018" @default.
- W2894580089 type Work @default.
- W2894580089 sameAs 2894580089 @default.
- W2894580089 citedByCount "1" @default.
- W2894580089 countsByYear W28945800892020 @default.
- W2894580089 crossrefType "posted-content" @default.