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- W2894581993 abstract "Activity of the human long interspersed nuclear elements-1 (LINE-1) retrotransposon occurs mainly in early embryonic development and during hippocampal neurogenesis. SOX-11, a transcription factor relevant to neuronal development, has unknown functions in the control of LINE-1 retrotransposon activity during neuronal differentiation. To study the dependence of LINE-1 activity on SOX-11 during neuronal differentiation, we induced differentiation of human SH-SY5Y neuroblastoma cells and adult adipose mesenchymal stem cells (hASCs) to a neuronal fate and found increased LINE-1 activity. We also show that SOX-11 protein binding to the LINE-1 promoter is higher in differentiating neuroblastoma cells, while knock-down of SOX-11 inhibits the induction of LINE-1 transcription in differentiating conditions. These results suggest that activation of LINE-1 retrotransposition during neuronal differentiation is mediated by SOX-11." @default.
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- W2894581993 date "2018-10-23" @default.
- W2894581993 modified "2023-10-05" @default.
- W2894581993 title "<scp>SOX</scp> ‐11 regulates <scp>LINE</scp> ‐1 retrotransposon activity during neuronal differentiation" @default.
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- W2894581993 doi "https://doi.org/10.1002/1873-3468.13260" @default.
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