FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894582147> ?p ?o ?g. }

• W2894582147 endingPage "e1006451" @default.
• W2894582147 startingPage "e1006451" @default.
• W2894582147 abstract "Recent advances in epigenomics have made it possible to map genome-wide regulatory regions using empirical methods. Subsequent comparative epigenomic studies have revealed that regulatory regions diverge rapidly between genome of different species, and that the divergence is more pronounced in enhancers than in promoters. To understand genomic changes underlying these patterns, we investigated if we can identify specific sequence fragments that are over-enriched in regulatory regions, thus potentially contributing to regulatory functions of such regions. Here we report numerous sequence fragments that are statistically over-enriched in enhancers and promoters of different mammals (which we refer to as 'sequence determinants'). Interestingly, the degree of statistical enrichment, which presumably is associated with the degree of regulatory impacts of the specific sequence determinant, was significantly higher for promoter sequence determinants than enhancer sequence determinants. We further used a machine learning method to construct prediction models using sequence determinants. Remarkably, prediction models constructed from one species could be used to predict regulatory regions of other species with high accuracy. This observation indicates that even though the precise locations of regulatory regions diverge rapidly during evolution, the functional potential of sequence determinants underlying regulatory sequences may be conserved between species." @default.
• W2894582147 created "2018-10-12" @default.
• W2894582147 creator A5001526423 @default.
• W2894582147 creator A5021812132 @default.
• W2894582147 creator A5033028005 @default.
• W2894582147 creator A5084213906 @default.
• W2894582147 date "2018-10-05" @default.
• W2894582147 modified "2023-10-16" @default.
• W2894582147 title "Functional conservation of sequence determinants at rapidly evolving regulatory regions across mammals" @default.
• W2894582147 cites W1964733653 @default.
• W2894582147 cites W1976526581 @default.
• W2894582147 cites W1976734415 @default.
• W2894582147 cites W1981030303 @default.
• W2894582147 cites W1982424675 @default.
• W2894582147 cites W1984563220 @default.
• W2894582147 cites W1988871238 @default.
• W2894582147 cites W1996601092 @default.
• W2894582147 cites W1996760543 @default.
• W2894582147 cites W2008807237 @default.
• W2894582147 cites W2017474677 @default.
• W2894582147 cites W2022936129 @default.
• W2894582147 cites W2033202128 @default.
• W2894582147 cites W2038584294 @default.
• W2894582147 cites W2039923266 @default.
• W2894582147 cites W2041171293 @default.
• W2894582147 cites W2076729646 @default.
• W2894582147 cites W2078757082 @default.
• W2894582147 cites W2085384621 @default.
• W2894582147 cites W2087892194 @default.
• W2894582147 cites W2095005830 @default.
• W2894582147 cites W2095903180 @default.
• W2894582147 cites W2097311877 @default.
• W2894582147 cites W2097360283 @default.
• W2894582147 cites W2100203037 @default.
• W2894582147 cites W2102245166 @default.
• W2894582147 cites W2102634667 @default.
• W2894582147 cites W2103777723 @default.
• W2894582147 cites W2108145648 @default.
• W2894582147 cites W2110065044 @default.
• W2894582147 cites W2112081648 @default.
• W2894582147 cites W2119867435 @default.
• W2894582147 cites W2122825543 @default.
• W2894582147 cites W2126796035 @default.
• W2894582147 cites W2127230663 @default.
• W2894582147 cites W2131669390 @default.
• W2894582147 cites W2134868027 @default.
• W2894582147 cites W2136889170 @default.
• W2894582147 cites W2138245520 @default.
• W2894582147 cites W2139427967 @default.
• W2894582147 cites W2140538490 @default.
• W2894582147 cites W2144857133 @default.
• W2894582147 cites W2146784048 @default.
• W2894582147 cites W2153981891 @default.
• W2894582147 cites W2161527747 @default.
• W2894582147 cites W2167764944 @default.
• W2894582147 cites W2176034226 @default.
• W2894582147 cites W2318027376 @default.
• W2894582147 cites W2463708289 @default.
• W2894582147 cites W4294541781 @default.
• W2894582147 doi "https://doi.org/10.1371/journal.pcbi.1006451" @default.
• W2894582147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192654" @default.
• W2894582147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30289877" @default.
• W2894582147 hasPublicationYear "2018" @default.
• W2894582147 type Work @default.
• W2894582147 sameAs 2894582147 @default.
• W2894582147 citedByCount "9" @default.
• W2894582147 countsByYear W28945821472020 @default.
• W2894582147 countsByYear W28945821472021 @default.
• W2894582147 countsByYear W28945821472022 @default.
• W2894582147 crossrefType "journal-article" @default.
• W2894582147 hasAuthorship W2894582147A5001526423 @default.
• W2894582147 hasAuthorship W2894582147A5021812132 @default.
• W2894582147 hasAuthorship W2894582147A5033028005 @default.
• W2894582147 hasAuthorship W2894582147A5084213906 @default.
• W2894582147 hasBestOaLocation W28945821471 @default.
• W2894582147 hasConcept C104317684 @default.
• W2894582147 hasConcept C111936080 @default.
• W2894582147 hasConcept C121912465 @default.
• W2894582147 hasConcept C141231307 @default.
• W2894582147 hasConcept C150194340 @default.
• W2894582147 hasConcept C165864922 @default.
• W2894582147 hasConcept C167625842 @default.
• W2894582147 hasConcept C190727270 @default.
• W2894582147 hasConcept C199216141 @default.
• W2894582147 hasConcept C21592294 @default.
• W2894582147 hasConcept C2778112365 @default.
• W2894582147 hasConcept C3017666073 @default.
• W2894582147 hasConcept C45484198 @default.
• W2894582147 hasConcept C54355233 @default.
• W2894582147 hasConcept C61053724 @default.
• W2894582147 hasConcept C70721500 @default.
• W2894582147 hasConcept C78458016 @default.
• W2894582147 hasConcept C86339819 @default.
• W2894582147 hasConcept C86803240 @default.
• W2894582147 hasConceptScore W2894582147C104317684 @default.
• W2894582147 hasConceptScore W2894582147C111936080 @default.
• W2894582147 hasConceptScore W2894582147C121912465 @default.
• W2894582147 hasConceptScore W2894582147C141231307 @default.

• next