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- W2894582184 abstract "The ability to design detergents that are suitable for protein analysis by mass spectrometry (MS) represents an on-going challenge in the field of native MS. Desirable detergent characteristics include charge-reducing properties and low gas-phase stabilities of complexes formed with proteins. In this work, the gas-phase properties of oligoglycerol detergents (OGDs) are optimized by fine tuning of their molecular structure. Furthermore, a tandem mass spectrometry (MS/MS) approach is presented that estimates the gas-phase properties of detergents simply by studying the dissociation behaviour of protein-detergent complexes (PDCs) formed with the soluble protein β-lactoglobulin (BLG). Graphical Abstract ᅟ." @default.
- W2894582184 created "2018-10-12" @default.
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- W2894582184 date "2018-10-01" @default.
- W2894582184 modified "2023-10-17" @default.
- W2894582184 title "Exploring the Potential of Dendritic Oligoglycerol Detergents for Protein Mass Spectrometry" @default.
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- W2894582184 doi "https://doi.org/10.1007/s13361-018-2063-2" @default.
- W2894582184 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6318253" @default.
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