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- W289458345 abstract "Publisher Summary This chapter discusses the activation of dopaminergic neurons by sulpiride. Sulpiride is an atypical neuroleptic because within a given dose range, it has various effects—it produces catalepsy only at toxic doses, it does not block apomorphine induced stereotypy, and in particular, it fails to block dopamine (DA) sensitive adenylate cyclase (AC) both in vitro and in vivo. The chapter presents the effects of sulpiride on the electrical activity of single identified DA neurons in the rat substantia nigra (SN) to clarify whether the increased dopaminergic activity elicited by neuroleptics was mediated by the blockade of D1 or D2 receptors. The present results show that intravenously injected (-)-sulpiride, but not the (+) enantiomer, increases the firing rate of DA cells in the SN and antagonizes apomorphine-induced inhibition of firing. Moreover, the local microiontophoretic application of (-)-sulpiride fails to interfere with the basal activity of DA cells in the SN, but prevents the DA-induced inhibition in these neurons." @default.
- W289458345 created "2016-06-24" @default.
- W289458345 creator A5067701124 @default.
- W289458345 date "1983-01-01" @default.
- W289458345 modified "2023-09-27" @default.
- W289458345 title "Activation of Dopaminergic Neurons by Sulpiride" @default.
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- W289458345 doi "https://doi.org/10.1016/b978-0-08-029804-7.50018-4" @default.
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