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- W2894584039 abstract "Background: Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) has gained acceptance for staging of tumors. A significant lower sensitivity for mucinous type histology (mainly in gastric and lung cancers) has been reported. Few data are available on diagnostic performance of the FDG PET/CT in patients with mucinous colorectal liver metastases (mucCRLM). Methods: A retrospective review of all patients treated for mucCRLM who had undergone FDG-PET/CT at our institution from 2004 and 2017 was performed. The original clinical PET interpretation was used. The reference standard was given by histology and/or follow-up imaging. Tumors comprising more than 50% mucinous carcinoma were diagnosed pathologically as mucCRLM. Diagnostic performance was assessed in organ and lesion -based. Results: 831 patients undergoing liver resections for CRLM between 01/2004 and 11/2017, 131 had mucinous CRLM (15.7%). FDG-PET/CT was performed in 58 (44.2%) patients. According to pathological and follow-up data 171 hepatic lesions were detected. FGD PET/CT confirmed 71 of them in 51 patients. 1 patient with negative FDG PET/CT had a complete pathological response. 12 (20.6%) patients presented a total of 13 extrahepatic deposits. In the organ-based assessment FDG-PET/CT had the sensitivity and specificity of 89.4% and 100% for hepatic metastases, 66.7% and 95.6% for lung metastases and 62.5% and 97.8% for lymph node metastases. In the lesion-based analysis the sensitivity and the specificity for liver metastases were 60.7% and 93.4%, respectively. Conclusion: The limited value of FDG PET/CT in the mucinous histologic type is confirmed in patients with hepatic and extrahepatic metastases from colorectal cancer." @default.
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- W2894584039 date "2018-09-01" @default.
- W2894584039 modified "2023-09-30" @default.
- W2894584039 title "Diagnostic performance of the FDG PET/CT in patients with mucinous colorectal liver metastases" @default.
- W2894584039 doi "https://doi.org/10.1016/j.hpb.2018.06.2567" @default.
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