FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894585820> ?p ?o ?g. }

• W2894585820 endingPage "1510" @default.
• W2894585820 startingPage "1498" @default.
• W2894585820 abstract "Some studies have shown that transplanted fat tissues usually cannot survive for long if adipose-derived stem cells (ADSCs) are removed from the tissues in advance. It is more meaningful to explore the mechanism mediating survival and differentiation of ADSCs in the transplanted microenvironment. AMP-activated protein kinase (AMPK) has been shown to be one of the energy receptors that regulate many aspects of cellular metabolism. AMPK activation has been implicated in models of adult ischemic injury, but the mechanism and the regulating effects of AMPK on survival and adipogenesis of transplanted ADSCs are still little known. In this study, we simulated the transplanted microenvironment using oxygen-glucose deprivation (OGD) to test the survival and adipogenesis of ADSCs. We found that OGD treatment triggered significant apoptosis and promoted autophagy. Simultaneously, OGD hindered the differentiation of ADSCs into mature adipocytes. After inhibiting AMPK, the OGD-induced apoptosis rate increased but autophagy was inhibited. The adipogenesis level also decreased. To show that the effects of AMPK on apoptosis and adipogenesis were autophagy-dependent, we pre-inhibited or pre-promoted autophagy with siATG7 or rapamycin while blocking AMPK. We found that inhibiting or improving autophagy exacerbated or alleviated the role of AMPK prohibition in apoptosis and adipogenesis. Furthermore, we showed that AMPK inhibition significantly lowered ULK1 activity but promoted mTOR activity, so that to inhibit autophagy. Our study shows that AMPK plays a protective role in maintaining survival and adipogenesis of OGD-challenged ADSCs partly by positively regulating autophagy. AMPK positively regulates autophagy by inhibiting mTOR but promoting ULK1 activity in OGD condition." @default.
• W2894585820 created "2018-10-12" @default.
• W2894585820 creator A5004794322 @default.
• W2894585820 creator A5033540244 @default.
• W2894585820 creator A5036709413 @default.
• W2894585820 creator A5060313435 @default.
• W2894585820 creator A5065117429 @default.
• W2894585820 creator A5068523039 @default.
• W2894585820 creator A5086559201 @default.
• W2894585820 date "2018-12-01" @default.
• W2894585820 modified "2023-10-09" @default.
• W2894585820 title "AMPK promotes survival and adipogenesis of ischemia-challenged ADSCs in an autophagy-dependent manner" @default.
• W2894585820 cites W1559210758 @default.
• W2894585820 cites W1874408158 @default.
• W2894585820 cites W1970637701 @default.
• W2894585820 cites W1971046557 @default.
• W2894585820 cites W1971396850 @default.
• W2894585820 cites W1974387131 @default.
• W2894585820 cites W1989045072 @default.
• W2894585820 cites W1999143228 @default.
• W2894585820 cites W2005303705 @default.
• W2894585820 cites W2008508884 @default.
• W2894585820 cites W2011349933 @default.
• W2894585820 cites W2016752484 @default.
• W2894585820 cites W2049368067 @default.
• W2894585820 cites W2049528479 @default.
• W2894585820 cites W2058366567 @default.
• W2894585820 cites W2061075485 @default.
• W2894585820 cites W2065720448 @default.
• W2894585820 cites W2068962109 @default.
• W2894585820 cites W2093037778 @default.
• W2894585820 cites W2103127964 @default.
• W2894585820 cites W2103628478 @default.
• W2894585820 cites W2103659405 @default.
• W2894585820 cites W2116186692 @default.
• W2894585820 cites W2136607709 @default.
• W2894585820 cites W2138671479 @default.
• W2894585820 cites W2162979490 @default.
• W2894585820 cites W2171144699 @default.
• W2894585820 cites W2173681478 @default.
• W2894585820 cites W2273828757 @default.
• W2894585820 cites W2322925987 @default.
• W2894585820 cites W2326080639 @default.
• W2894585820 cites W2399249680 @default.
• W2894585820 cites W2536165931 @default.
• W2894585820 cites W2598388543 @default.
• W2894585820 cites W2625269145 @default.
• W2894585820 cites W2725368921 @default.
• W2894585820 cites W2734060969 @default.
• W2894585820 cites W2760165507 @default.
• W2894585820 cites W2773897695 @default.
• W2894585820 cites W2792066366 @default.
• W2894585820 cites W2796990717 @default.
• W2894585820 cites W3012391886 @default.
• W2894585820 doi "https://doi.org/10.1016/j.bbalip.2018.10.002" @default.
• W2894585820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296594" @default.
• W2894585820 hasPublicationYear "2018" @default.
• W2894585820 type Work @default.
• W2894585820 sameAs 2894585820 @default.
• W2894585820 citedByCount "9" @default.
• W2894585820 countsByYear W28945858202020 @default.
• W2894585820 countsByYear W28945858202021 @default.
• W2894585820 countsByYear W28945858202022 @default.
• W2894585820 countsByYear W28945858202023 @default.
• W2894585820 crossrefType "journal-article" @default.
• W2894585820 hasAuthorship W2894585820A5004794322 @default.
• W2894585820 hasAuthorship W2894585820A5033540244 @default.
• W2894585820 hasAuthorship W2894585820A5036709413 @default.
• W2894585820 hasAuthorship W2894585820A5060313435 @default.
• W2894585820 hasAuthorship W2894585820A5065117429 @default.
• W2894585820 hasAuthorship W2894585820A5068523039 @default.
• W2894585820 hasAuthorship W2894585820A5086559201 @default.
• W2894585820 hasConcept C11960822 @default.
• W2894585820 hasConcept C122927707 @default.
• W2894585820 hasConcept C134018914 @default.
• W2894585820 hasConcept C171089720 @default.
• W2894585820 hasConcept C185592680 @default.
• W2894585820 hasConcept C190283241 @default.
• W2894585820 hasConcept C198826908 @default.
• W2894585820 hasConcept C203522944 @default.
• W2894585820 hasConcept C2776780712 @default.
• W2894585820 hasConcept C2780124434 @default.
• W2894585820 hasConcept C502942594 @default.
• W2894585820 hasConcept C55493867 @default.
• W2894585820 hasConcept C62478195 @default.
• W2894585820 hasConcept C71680706 @default.
• W2894585820 hasConcept C86554907 @default.
• W2894585820 hasConcept C86803240 @default.
• W2894585820 hasConcept C95444343 @default.
• W2894585820 hasConcept C97029542 @default.
• W2894585820 hasConceptScore W2894585820C11960822 @default.
• W2894585820 hasConceptScore W2894585820C122927707 @default.
• W2894585820 hasConceptScore W2894585820C134018914 @default.
• W2894585820 hasConceptScore W2894585820C171089720 @default.
• W2894585820 hasConceptScore W2894585820C185592680 @default.
• W2894585820 hasConceptScore W2894585820C190283241 @default.
• W2894585820 hasConceptScore W2894585820C198826908 @default.
• W2894585820 hasConceptScore W2894585820C203522944 @default.

• next