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- W2894592287 abstract "Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among gastrointestinal malignancies despite of existing multimodal therapies. Circulating cell-free DNA (cfDNA) can be used for cancer diagnosis and prediction of treatment response. The aim of this study was to investigate whether KRAS mutations at codon 12/13 in cfDNA of preoperative and postoperative sera from PDAC patients can serve as a predictive biomarker of treatment response and outcomes after surgery. Pre- and postoperative serum samples obtained from PDAC patients who underwent curative pancreatectomy at our institution between January 2013 and July 2016 were retrospectively analyzed. Peptide nucleic acid (PNA)-directed PCR clamping was used to identify KRAS mutations in cfDNA and a Cox proportional hazards model was employed to determine prognostic factors for PDAC after surgery. Among 45 enrolled patients, 11 (24.4%) and 20 (44.4%) had KRAS mutations in cfDNA from preoperative and postoperative sera, respectively. Multivariate analysis revealed that KRAS mutations in postoperative serum (hazard ratio [HR] = 2.919; 95% confidence interval [CI] = 1.109–5.621; P = 0.027) was an independent prognostic factor for disease-free survival. Furthermore, the shift from the wild type KRAS in preoperative to mutant KRAS in postoperative cfDNA (HR = 9.419; 95% Cl = 2.015–44.036; P = 0.004), as well as neural infiltration (HR = 0.197; 95.0% CI: 0.044–0.876; P = 0.033) were independent prognostic factors for overall survival. In conclusion, changes in the KRAS mutation status between pre- and postoperative cfDNA may be a useful prediction biomarker of survival and treatment responses after surgery for PDAC patients." @default.
- W2894592287 created "2018-10-12" @default.
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- W2894592287 date "2018-09-01" @default.
- W2894592287 modified "2023-09-27" @default.
- W2894592287 title "KRAS mutations in cell-free DNA from pre- and postoperative sera as a pancreatic cancer marker" @default.
- W2894592287 doi "https://doi.org/10.1016/j.hpb.2018.06.2168" @default.
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