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- W2894594663 abstract "The design, synthesis and evaluation of a small series of potent amphiphilic norbornane antibacterial agents has been performed (compound 10 MIC = 0.25 μg/mL against MRSA). Molecular modelling indicates rapid aggregation of this class of antibacterial agent prior to membrane association and insertion. Two fluorescent analogues (compound 29 with 4-amino-naphthalimide and 34 with 4-nitrobenz-2-oxa-1,3-diazole fluorophores) with good activity (MIC = 0.5 μg/mL against MRSA) were also constructed and confocal microscopy studies indicate that the primary site of interaction for this family of compounds is the bacterial membrane." @default.
- W2894594663 created "2018-10-12" @default.
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- W2894594663 date "2018-12-01" @default.
- W2894594663 modified "2023-10-16" @default.
- W2894594663 title "Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane" @default.
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- W2894594663 doi "https://doi.org/10.1016/j.ejmech.2018.09.072" @default.
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