FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894596066> ?p ?o ?g. }

• W2894596066 abstract "Abstract This study aimed to investigate the effect of bone marrow-derived mesenchymal stem cells (BMSCs) on disseminated intravascular coagulation (DIC) model rats and to further explore the underlying mechanism. A rat model of lipopolysaccharide (LPS)-induced DIC was successfully established, as indicated by impaired plasma hemostatic parameters and damaged organ functions in rats. Importantly, pre-treatment with rat allogeneic BMSCs before LPS injection significantly alleviated systemic intravascular coagulation, reduced plasma levels of organ dysfunction indicators and pro-inflammatory cytokines, suppressed fibrin microthrombi formation, ameliorated liver, heart, and renal injuries, and increased 24-hour survival rates in LPS-induced DIC rats. The protection of BMSCs against DIC was in a moderately dose-dependent manner. Further investigation revealed that BMSCs co-cultured with peripheral blood mononuclear cells (PBMCs) significantly inhibited the LPS-stimulated PBMCs proliferation and the release of pro-inflammatory cytokines from PBMCs. Of note, upregulation of immunosuppressive factors including indoleamine 2,3-dioxygenase and interleukin-10, which was induced by interferon-γ, contributed to BMSCs-mediated inhibition of LPS-stimulated PBMCs proliferation. These effects do not depend on the direct cell–cell contact. In conclusion, BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced DIC model rats. The protection of BMSCs may be attributed to their anti-inflammatory and immunomodulatory properties, which render BMSCs a promising source for stem cell-based therapeutic approaches in inflammation-related DIC." @default.
• W2894596066 created "2018-10-12" @default.
• W2894596066 creator A5016715625 @default.
• W2894596066 creator A5068317036 @default.
• W2894596066 creator A5075523709 @default.
• W2894596066 creator A5084249288 @default.
• W2894596066 creator A5085142676 @default.
• W2894596066 date "2018-10-03" @default.
• W2894596066 modified "2023-10-12" @default.
• W2894596066 title "BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model" @default.
• W2894596066 cites W162447880 @default.
• W2894596066 cites W1964632668 @default.
• W2894596066 cites W1967499351 @default.
• W2894596066 cites W1968159361 @default.
• W2894596066 cites W1987736263 @default.
• W2894596066 cites W1992270199 @default.
• W2894596066 cites W1997446231 @default.
• W2894596066 cites W1998194680 @default.
• W2894596066 cites W2005477804 @default.
• W2894596066 cites W2009111653 @default.
• W2894596066 cites W2012968942 @default.
• W2894596066 cites W2016395601 @default.
• W2894596066 cites W2019495971 @default.
• W2894596066 cites W2020114480 @default.
• W2894596066 cites W2025371271 @default.
• W2894596066 cites W2028244257 @default.
• W2894596066 cites W2030653181 @default.
• W2894596066 cites W2030778014 @default.
• W2894596066 cites W2044695442 @default.
• W2894596066 cites W2055767345 @default.
• W2894596066 cites W2086677068 @default.
• W2894596066 cites W2089390485 @default.
• W2894596066 cites W2095666785 @default.
• W2894596066 cites W2102726602 @default.
• W2894596066 cites W2111727066 @default.
• W2894596066 cites W2119939110 @default.
• W2894596066 cites W2126134953 @default.
• W2894596066 cites W2146663354 @default.
• W2894596066 cites W2159358845 @default.
• W2894596066 cites W2223214578 @default.
• W2894596066 cites W2286528644 @default.
• W2894596066 cites W2318714208 @default.
• W2894596066 cites W233151749 @default.
• W2894596066 cites W2413673244 @default.
• W2894596066 cites W2471897020 @default.
• W2894596066 cites W2521043421 @default.
• W2894596066 cites W2551096367 @default.
• W2894596066 cites W2594508174 @default.
• W2894596066 cites W2600218619 @default.
• W2894596066 cites W2604433229 @default.
• W2894596066 cites W2604494781 @default.
• W2894596066 cites W2781213254 @default.
• W2894596066 cites W2884786019 @default.
• W2894596066 cites W2976164949 @default.
• W2894596066 cites W61048274 @default.
• W2894596066 doi "https://doi.org/10.1038/s41419-018-1060-5" @default.
• W2894596066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170466" @default.
• W2894596066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282969" @default.
• W2894596066 hasPublicationYear "2018" @default.
• W2894596066 type Work @default.
• W2894596066 sameAs 2894596066 @default.
• W2894596066 citedByCount "9" @default.
• W2894596066 countsByYear W28945960662019 @default.
• W2894596066 countsByYear W28945960662020 @default.
• W2894596066 countsByYear W28945960662021 @default.
• W2894596066 countsByYear W28945960662022 @default.
• W2894596066 countsByYear W28945960662023 @default.
• W2894596066 crossrefType "journal-article" @default.
• W2894596066 hasAuthorship W2894596066A5016715625 @default.
• W2894596066 hasAuthorship W2894596066A5068317036 @default.
• W2894596066 hasAuthorship W2894596066A5075523709 @default.
• W2894596066 hasAuthorship W2894596066A5084249288 @default.
• W2894596066 hasAuthorship W2894596066A5085142676 @default.
• W2894596066 hasBestOaLocation W28945960661 @default.
• W2894596066 hasConcept C104317684 @default.
• W2894596066 hasConcept C127561419 @default.
• W2894596066 hasConcept C137061746 @default.
• W2894596066 hasConcept C142724271 @default.
• W2894596066 hasConcept C164027704 @default.
• W2894596066 hasConcept C185592680 @default.
• W2894596066 hasConcept C198826908 @default.
• W2894596066 hasConcept C202751555 @default.
• W2894596066 hasConcept C203014093 @default.
• W2894596066 hasConcept C2776914184 @default.
• W2894596066 hasConcept C2778734968 @default.
• W2894596066 hasConcept C2778754761 @default.
• W2894596066 hasConcept C2780007613 @default.
• W2894596066 hasConcept C54173615 @default.
• W2894596066 hasConcept C55493867 @default.
• W2894596066 hasConcept C71924100 @default.
• W2894596066 hasConcept C98274493 @default.
• W2894596066 hasConceptScore W2894596066C104317684 @default.
• W2894596066 hasConceptScore W2894596066C127561419 @default.
• W2894596066 hasConceptScore W2894596066C137061746 @default.
• W2894596066 hasConceptScore W2894596066C142724271 @default.
• W2894596066 hasConceptScore W2894596066C164027704 @default.
• W2894596066 hasConceptScore W2894596066C185592680 @default.
• W2894596066 hasConceptScore W2894596066C198826908 @default.
• W2894596066 hasConceptScore W2894596066C202751555 @default.
• W2894596066 hasConceptScore W2894596066C203014093 @default.

• next