SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894598243> ?p ?o ?g. }

Showing items 1 to 100 of ±182 with 100 items per page.

W2894598243 abstract "Abstract All breast cancers are assessed for levels of human epidermal growth factor receptor 2 (HER2). Fluorescence in situ hybridization (FISH) and immunohistochemistry are currently used to determine if a patient is eligible for anti-HER2 therapy. Limitations of both tests include variability and relatively long processing times. Additionally, neither test determines whether HER2 contains the extracellular domain. While truncated in some tumors, this domain is required for binding of the therapeutic antibody trastuzumab. Here, trastuzumab was used to directly detect HER2 with quantitative single molecule localization microscopy (qSMLM). In proof of concept studies, our new method rapidly quantified both HER2 density and features of nano-organization. In cultured cells, the method was sensitive to subtle variations in HER2 expression. To assess patient samples, we combined qSMLM with tissue touch preparation (touch prep-qSMLM) and examined large areas of intact membranes. For cell lines and patient samples, HER2 copy numbers from FISH showed a significant positive correlation with detected densities from qSMLM and trended with HER2 cluster occupancy." @default.
W2894598243 created "2018-10-12" @default.
W2894598243 creator A5003378933 @default.
W2894598243 creator A5013007732 @default.
W2894598243 creator A5030534980 @default.
W2894598243 creator A5031678728 @default.
W2894598243 creator A5050914942 @default.
W2894598243 creator A5058020504 @default.
W2894598243 date "2018-10-11" @default.
W2894598243 modified "2023-10-16" @default.
W2894598243 title "Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2" @default.
W2894598243 cites W1593655000 @default.
W2894598243 cites W1772131958 @default.
W2894598243 cites W1964321121 @default.
W2894598243 cites W1969103349 @default.
W2894598243 cites W1971267920 @default.
W2894598243 cites W1992858116 @default.
W2894598243 cites W2004851762 @default.
W2894598243 cites W2005446948 @default.
W2894598243 cites W2018211174 @default.
W2894598243 cites W2018649145 @default.
W2894598243 cites W2023681515 @default.
W2894598243 cites W2031473351 @default.
W2894598243 cites W2039194640 @default.
W2894598243 cites W2043398720 @default.
W2894598243 cites W2043891370 @default.
W2894598243 cites W2044702943 @default.
W2894598243 cites W2048142144 @default.
W2894598243 cites W2051206690 @default.
W2894598243 cites W2051365199 @default.
W2894598243 cites W2053129129 @default.
W2894598243 cites W2054455698 @default.
W2894598243 cites W2065154098 @default.
W2894598243 cites W2078454159 @default.
W2894598243 cites W2079078036 @default.
W2894598243 cites W2089288294 @default.
W2894598243 cites W2091141762 @default.
W2894598243 cites W2095659509 @default.
W2894598243 cites W2097255042 @default.
W2894598243 cites W2101336703 @default.
W2894598243 cites W2101577390 @default.
W2894598243 cites W2101824720 @default.
W2894598243 cites W2101979288 @default.
W2894598243 cites W2103241853 @default.
W2894598243 cites W2103782445 @default.
W2894598243 cites W2104528117 @default.
W2894598243 cites W2107413762 @default.
W2894598243 cites W2108217314 @default.
W2894598243 cites W2108959691 @default.
W2894598243 cites W2114941442 @default.
W2894598243 cites W2115759102 @default.
W2894598243 cites W2119672124 @default.
W2894598243 cites W2121131635 @default.
W2894598243 cites W2133161896 @default.
W2894598243 cites W2140584756 @default.
W2894598243 cites W2141393790 @default.
W2894598243 cites W2143668948 @default.
W2894598243 cites W2152494192 @default.
W2894598243 cites W2154776646 @default.
W2894598243 cites W2157719382 @default.
W2894598243 cites W2166311434 @default.
W2894598243 cites W2172265576 @default.
W2894598243 cites W2177010824 @default.
W2894598243 cites W2259802687 @default.
W2894598243 cites W2291927913 @default.
W2894598243 cites W2308770204 @default.
W2894598243 cites W2473214546 @default.
W2894598243 cites W2507407426 @default.
W2894598243 cites W2511064907 @default.
W2894598243 cites W2516815115 @default.
W2894598243 cites W2525268340 @default.
W2894598243 cites W2526809862 @default.
W2894598243 cites W2574196822 @default.
W2894598243 cites W2585216972 @default.
W2894598243 cites W2596809090 @default.
W2894598243 cites W2597088123 @default.
W2894598243 cites W2614676433 @default.
W2894598243 cites W2618764704 @default.
W2894598243 cites W2627019357 @default.
W2894598243 cites W2683152696 @default.
W2894598243 cites W2765381479 @default.
W2894598243 cites W2785793017 @default.
W2894598243 cites W2806209829 @default.
W2894598243 cites W2807025364 @default.
W2894598243 cites W4239989216 @default.
W2894598243 cites W4249458773 @default.
W2894598243 doi "https://doi.org/10.1038/s41598-018-33225-0" @default.
W2894598243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6181918" @default.
W2894598243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310083" @default.
W2894598243 hasPublicationYear "2018" @default.
W2894598243 type Work @default.
W2894598243 sameAs 2894598243 @default.
W2894598243 citedByCount "26" @default.
W2894598243 countsByYear W28945982432019 @default.
W2894598243 countsByYear W28945982432020 @default.
W2894598243 countsByYear W28945982432021 @default.
W2894598243 countsByYear W28945982432022 @default.
W2894598243 countsByYear W28945982432023 @default.
W2894598243 crossrefType "journal-article" @default.
W2894598243 hasAuthorship W2894598243A5003378933 @default.