Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894598387> ?p ?o ?g. }
- W2894598387 endingPage "885" @default.
- W2894598387 startingPage "876" @default.
- W2894598387 abstract "Primary myelofibrosis (PMF) is the most aggressive Philadelphia-negative (Ph-) myeloproliferative neoplasm (MPN), characterized by bone marrow (BM) insufficiency, myelofibrosis (MF), osteosclerosis, neoangiogenesis, and extramedullary hematopoiesis (EMH) in spleen and liver. Presently, there is no curative treatment for this disease and therapy consists primarily of symptom relief and, in selected cases, allogeneic hematopoietic stem cell transplant (alloHSCT). PMF's major defining characteristics, as well as several recently described aspects of its cellular and molecular pathophysiology all support a critical role for dysregulated cell-cell/cell-extracellular matrix interactions and cytokine/chemokine signaling within the BM niche in the natural history of this disease. This review will highlight current data concerning the involvement of the BM niche, particularly of mesenchymal stem cells (MSC), in PMF, and will then discuss the rationale for a stroma-directed treatment, and the advantages such an approach would offer over the current treatments focused on targeting the malignant clone." @default.
- W2894598387 created "2018-10-12" @default.
- W2894598387 creator A5005397557 @default.
- W2894598387 creator A5021272539 @default.
- W2894598387 creator A5064374408 @default.
- W2894598387 creator A5079717295 @default.
- W2894598387 creator A5086144565 @default.
- W2894598387 date "2018-10-02" @default.
- W2894598387 modified "2023-10-16" @default.
- W2894598387 title "Mesenchymal stem cells in myeloproliferative disorders – focus on primary myelofibrosis" @default.
- W2894598387 cites W1484297986 @default.
- W2894598387 cites W1489267752 @default.
- W2894598387 cites W1593177553 @default.
- W2894598387 cites W1628611492 @default.
- W2894598387 cites W182715940 @default.
- W2894598387 cites W1898355244 @default.
- W2894598387 cites W1963679004 @default.
- W2894598387 cites W1966318910 @default.
- W2894598387 cites W1966408210 @default.
- W2894598387 cites W1967313061 @default.
- W2894598387 cites W1968628080 @default.
- W2894598387 cites W1985727076 @default.
- W2894598387 cites W1986852077 @default.
- W2894598387 cites W1990071623 @default.
- W2894598387 cites W1993072636 @default.
- W2894598387 cites W1994634026 @default.
- W2894598387 cites W1995162107 @default.
- W2894598387 cites W1997995008 @default.
- W2894598387 cites W2000642246 @default.
- W2894598387 cites W2009412018 @default.
- W2894598387 cites W2014091629 @default.
- W2894598387 cites W2018860059 @default.
- W2894598387 cites W2022292181 @default.
- W2894598387 cites W2025377583 @default.
- W2894598387 cites W2027337742 @default.
- W2894598387 cites W2027613124 @default.
- W2894598387 cites W2037736150 @default.
- W2894598387 cites W2043033876 @default.
- W2894598387 cites W2044569270 @default.
- W2894598387 cites W2048866300 @default.
- W2894598387 cites W2052033797 @default.
- W2894598387 cites W2055473022 @default.
- W2894598387 cites W2055548623 @default.
- W2894598387 cites W2056265113 @default.
- W2894598387 cites W2056278417 @default.
- W2894598387 cites W2057573037 @default.
- W2894598387 cites W2058357603 @default.
- W2894598387 cites W2058380732 @default.
- W2894598387 cites W2061144228 @default.
- W2894598387 cites W2069943416 @default.
- W2894598387 cites W2070793750 @default.
- W2894598387 cites W2076709820 @default.
- W2894598387 cites W2081805822 @default.
- W2894598387 cites W2085603059 @default.
- W2894598387 cites W2087854083 @default.
- W2894598387 cites W2089654938 @default.
- W2894598387 cites W2100063372 @default.
- W2894598387 cites W2103398208 @default.
- W2894598387 cites W2106609638 @default.
- W2894598387 cites W2108585990 @default.
- W2894598387 cites W2111141291 @default.
- W2894598387 cites W2113062534 @default.
- W2894598387 cites W2123105952 @default.
- W2894598387 cites W2123633897 @default.
- W2894598387 cites W2129049052 @default.
- W2894598387 cites W2134919790 @default.
- W2894598387 cites W2137843072 @default.
- W2894598387 cites W2138546015 @default.
- W2894598387 cites W2143193295 @default.
- W2894598387 cites W2153979886 @default.
- W2894598387 cites W2157155777 @default.
- W2894598387 cites W2164450795 @default.
- W2894598387 cites W2165542165 @default.
- W2894598387 cites W2176681260 @default.
- W2894598387 cites W2192544655 @default.
- W2894598387 cites W2221262980 @default.
- W2894598387 cites W2275559463 @default.
- W2894598387 cites W2326795317 @default.
- W2894598387 cites W2339819953 @default.
- W2894598387 cites W2416281109 @default.
- W2894598387 cites W2493190817 @default.
- W2894598387 cites W2533306334 @default.
- W2894598387 cites W2548099047 @default.
- W2894598387 cites W2552928809 @default.
- W2894598387 cites W2582255114 @default.
- W2894598387 cites W2584024931 @default.
- W2894598387 cites W2587720292 @default.
- W2894598387 cites W2593745270 @default.
- W2894598387 cites W2607959672 @default.
- W2894598387 cites W2613365198 @default.
- W2894598387 cites W2624346565 @default.
- W2894598387 cites W2732945346 @default.
- W2894598387 cites W2752360943 @default.
- W2894598387 cites W2763659564 @default.
- W2894598387 cites W4236951935 @default.
- W2894598387 doi "https://doi.org/10.1080/10428194.2018.1516881" @default.
- W2894598387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30277128" @default.
- W2894598387 hasPublicationYear "2018" @default.