FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894600215> ?p ?o ?g. }

• W2894600215 endingPage "10755" @default.
• W2894600215 startingPage "10750" @default.
• W2894600215 abstract "The chemical diversity and known safety profiles of drugs previously tested in humans make them a valuable set of compounds to explore potential therapeutic utility in indications outside those originally targeted, especially neglected tropical diseases. This practice of drug repurposing has become commonplace in academic and other nonprofit drug-discovery efforts, with the appeal that significantly less time and resources are required to advance a candidate into the clinic. Here, we report a comprehensive open-access, drug repositioning screening set of 12,000 compounds (termed ReFRAME; Repurposing, Focused Rescue, and Accelerated Medchem) that was assembled by combining three widely used commercial drug competitive intelligence databases (Clarivate Integrity, GVK Excelra GoStar, and Citeline Pharmaprojects), together with extensive patent mining of small molecules that have been dosed in humans. To date, 12,000 compounds (∼80% of compounds identified from data mining) have been purchased or synthesized and subsequently plated for screening. To exemplify its utility, this collection was screened against Cryptosporidium spp., a major cause of childhood diarrhea in the developing world, and two active compounds previously tested in humans for other therapeutic indications were identified. Both compounds, VB-201 and a structurally related analog of ASP-7962, were subsequently shown to be efficacious in animal models of Cryptosporidium infection at clinically relevant doses, based on available human doses. In addition, an open-access data portal (https://reframedb.org) has been developed to share ReFRAME screen hits to encourage additional follow-up and maximize the impact of the ReFRAME screening collection." @default.
• W2894600215 created "2018-10-12" @default.
• W2894600215 creator A5004383877 @default.
• W2894600215 creator A5024377883 @default.
• W2894600215 creator A5025794761 @default.
• W2894600215 creator A5028788457 @default.
• W2894600215 creator A5032921408 @default.
• W2894600215 creator A5036730904 @default.
• W2894600215 creator A5038879049 @default.
• W2894600215 creator A5043445919 @default.
• W2894600215 creator A5045919184 @default.
• W2894600215 creator A5047852347 @default.
• W2894600215 creator A5057354862 @default.
• W2894600215 creator A5062707797 @default.
• W2894600215 creator A5066008654 @default.
• W2894600215 creator A5071332544 @default.
• W2894600215 creator A5072715950 @default.
• W2894600215 creator A5073227799 @default.
• W2894600215 creator A5079931299 @default.
• W2894600215 date "2018-10-03" @default.
• W2894600215 modified "2023-10-18" @default.
• W2894600215 title "The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis" @default.
• W2894600215 cites W1724046836 @default.
• W2894600215 cites W1998056319 @default.
• W2894600215 cites W1998724242 @default.
• W2894600215 cites W2015810688 @default.
• W2894600215 cites W2019402469 @default.
• W2894600215 cites W2108492672 @default.
• W2894600215 cites W2114053580 @default.
• W2894600215 cites W2128054164 @default.
• W2894600215 cites W2137632714 @default.
• W2894600215 cites W2154669492 @default.
• W2894600215 cites W2169678694 @default.
• W2894600215 cites W2339953272 @default.
• W2894600215 cites W2397640409 @default.
• W2894600215 cites W2444690946 @default.
• W2894600215 cites W2585183443 @default.
• W2894600215 cites W2604527271 @default.
• W2894600215 cites W2607291703 @default.
• W2894600215 cites W2615381373 @default.
• W2894600215 cites W2620271723 @default.
• W2894600215 cites W2752266791 @default.
• W2894600215 cites W2952216057 @default.
• W2894600215 cites W4244480450 @default.
• W2894600215 cites W4250877149 @default.
• W2894600215 doi "https://doi.org/10.1073/pnas.1810137115" @default.
• W2894600215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196526" @default.
• W2894600215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282735" @default.
• W2894600215 hasPublicationYear "2018" @default.
• W2894600215 type Work @default.
• W2894600215 sameAs 2894600215 @default.
• W2894600215 citedByCount "149" @default.
• W2894600215 countsByYear W28946002152018 @default.
• W2894600215 countsByYear W28946002152019 @default.
• W2894600215 countsByYear W28946002152020 @default.
• W2894600215 countsByYear W28946002152021 @default.
• W2894600215 countsByYear W28946002152022 @default.
• W2894600215 countsByYear W28946002152023 @default.
• W2894600215 crossrefType "journal-article" @default.
• W2894600215 hasAuthorship W2894600215A5004383877 @default.
• W2894600215 hasAuthorship W2894600215A5024377883 @default.
• W2894600215 hasAuthorship W2894600215A5025794761 @default.
• W2894600215 hasAuthorship W2894600215A5028788457 @default.
• W2894600215 hasAuthorship W2894600215A5032921408 @default.
• W2894600215 hasAuthorship W2894600215A5036730904 @default.
• W2894600215 hasAuthorship W2894600215A5038879049 @default.
• W2894600215 hasAuthorship W2894600215A5043445919 @default.
• W2894600215 hasAuthorship W2894600215A5045919184 @default.
• W2894600215 hasAuthorship W2894600215A5047852347 @default.
• W2894600215 hasAuthorship W2894600215A5057354862 @default.
• W2894600215 hasAuthorship W2894600215A5062707797 @default.
• W2894600215 hasAuthorship W2894600215A5066008654 @default.
• W2894600215 hasAuthorship W2894600215A5071332544 @default.
• W2894600215 hasAuthorship W2894600215A5072715950 @default.
• W2894600215 hasAuthorship W2894600215A5073227799 @default.
• W2894600215 hasAuthorship W2894600215A5079931299 @default.
• W2894600215 hasBestOaLocation W28946002151 @default.
• W2894600215 hasConcept C103637391 @default.
• W2894600215 hasConcept C151730666 @default.
• W2894600215 hasConcept C15744967 @default.
• W2894600215 hasConcept C187029079 @default.
• W2894600215 hasConcept C18903297 @default.
• W2894600215 hasConcept C2778877831 @default.
• W2894600215 hasConcept C2780035454 @default.
• W2894600215 hasConcept C41008148 @default.
• W2894600215 hasConcept C519536355 @default.
• W2894600215 hasConcept C60644358 @default.
• W2894600215 hasConcept C61716771 @default.
• W2894600215 hasConcept C71924100 @default.
• W2894600215 hasConcept C74187038 @default.
• W2894600215 hasConcept C77805123 @default.
• W2894600215 hasConcept C86803240 @default.
• W2894600215 hasConcept C98274493 @default.
• W2894600215 hasConceptScore W2894600215C103637391 @default.
• W2894600215 hasConceptScore W2894600215C151730666 @default.
• W2894600215 hasConceptScore W2894600215C15744967 @default.
• W2894600215 hasConceptScore W2894600215C187029079 @default.
• W2894600215 hasConceptScore W2894600215C18903297 @default.

• next