FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894613434> ?p ?o ?g. }

• W2894613434 endingPage "181" @default.
• W2894613434 startingPage "170" @default.
• W2894613434 abstract "Conjugating certain types of lentiviral vectors with targeting ligands can redirect the vectors to specifically transduce desired cell types. However, extensive genetic and/or biochemical manipulations are required for conjugation, which hinders applications for targeting lentiviral vectors for broader research fields. We developed envelope proteins fused with biotin-binding molecules to conjugate the pseudotyped vectors with biotinylated targeting molecules by simply mixing them. The envelope proteins fused with the monomeric, but not tetrameric, biotin-binding molecules can pseudotype lentiviral vectors and be conjugated with biotinylated targeting ligands. The conjugation is stable enough to redirect lentiviral transduction in the presence of serum, indicating their potential in in vivo . When a signaling molecule is conjugated with the vector, the conjugation facilitates transduction and signaling in a receptor-specific manner. This simple method of ligand conjugation and ease of obtaining various types of biotinylated ligands will make targeted lentiviral transduction easily applicable to broad fields of research. • We have developed lentiviral vectors whose tropisms can be redirected by conjugation with biotinylated targeting molecules. • Conjugation of targeting molecules is stable enough to transduce desired cell types in the presence of human serum. • This targeting system's simple conjugation method is ideal for many researchers to transduce cell types of their interest." @default.
• W2894613434 created "2018-10-12" @default.
• W2894613434 creator A5010476642 @default.
• W2894613434 creator A5042350728 @default.
• W2894613434 creator A5044800574 @default.
• W2894613434 creator A5074261771 @default.
• W2894613434 creator A5089050904 @default.
• W2894613434 date "2018-12-01" @default.
• W2894613434 modified "2023-09-24" @default.
• W2894613434 title "Versatile targeting system for lentiviral vectors involving biotinylated targeting molecules" @default.
• W2894613434 cites W1972636590 @default.
• W2894613434 cites W1981449360 @default.
• W2894613434 cites W1984412128 @default.
• W2894613434 cites W2000590004 @default.
• W2894613434 cites W2008483588 @default.
• W2894613434 cites W2009516769 @default.
• W2894613434 cites W2009541240 @default.
• W2894613434 cites W2009761723 @default.
• W2894613434 cites W2009994985 @default.
• W2894613434 cites W2013923368 @default.
• W2894613434 cites W2014539773 @default.
• W2894613434 cites W2015552915 @default.
• W2894613434 cites W2019508559 @default.
• W2894613434 cites W2020648658 @default.
• W2894613434 cites W2021227042 @default.
• W2894613434 cites W2022939759 @default.
• W2894613434 cites W2024569107 @default.
• W2894613434 cites W2025134240 @default.
• W2894613434 cites W2031981197 @default.
• W2894613434 cites W2032997786 @default.
• W2894613434 cites W2033395152 @default.
• W2894613434 cites W2033624540 @default.
• W2894613434 cites W2039088710 @default.
• W2894613434 cites W2045508835 @default.
• W2894613434 cites W2046020883 @default.
• W2894613434 cites W2047560976 @default.
• W2894613434 cites W2048782315 @default.
• W2894613434 cites W2049140420 @default.
• W2894613434 cites W2062078127 @default.
• W2894613434 cites W2065473039 @default.
• W2894613434 cites W2067471829 @default.
• W2894613434 cites W2069301738 @default.
• W2894613434 cites W2075227748 @default.
• W2894613434 cites W2078224854 @default.
• W2894613434 cites W2081703066 @default.
• W2894613434 cites W2087563355 @default.
• W2894613434 cites W2092289486 @default.
• W2894613434 cites W2097286866 @default.
• W2894613434 cites W2097496529 @default.
• W2894613434 cites W2099063881 @default.
• W2894613434 cites W2101666840 @default.
• W2894613434 cites W2105291981 @default.
• W2894613434 cites W2108047557 @default.
• W2894613434 cites W2114717414 @default.
• W2894613434 cites W2117622183 @default.
• W2894613434 cites W2122319441 @default.
• W2894613434 cites W2128008808 @default.
• W2894613434 cites W2131317050 @default.
• W2894613434 cites W2136274459 @default.
• W2894613434 cites W2138678467 @default.
• W2894613434 cites W2147640800 @default.
• W2894613434 cites W2151382145 @default.
• W2894613434 cites W2152204052 @default.
• W2894613434 cites W2158294831 @default.
• W2894613434 cites W2171985637 @default.
• W2894613434 cites W2230854729 @default.
• W2894613434 cites W2264612298 @default.
• W2894613434 cites W2308044136 @default.
• W2894613434 cites W2412797997 @default.
• W2894613434 cites W2414040529 @default.
• W2894613434 cites W2414949282 @default.
• W2894613434 cites W2518229080 @default.
• W2894613434 cites W2521113002 @default.
• W2894613434 cites W2738087216 @default.
• W2894613434 cites W2774792714 @default.
• W2894613434 cites W2804231581 @default.
• W2894613434 cites W2883177948 @default.
• W2894613434 cites W4237271597 @default.
• W2894613434 cites W964558111 @default.
• W2894613434 doi "https://doi.org/10.1016/j.virol.2018.09.017" @default.
• W2894613434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6269213" @default.
• W2894613434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30290312" @default.
• W2894613434 hasPublicationYear "2018" @default.
• W2894613434 type Work @default.
• W2894613434 sameAs 2894613434 @default.
• W2894613434 citedByCount "6" @default.
• W2894613434 countsByYear W28946134342020 @default.
• W2894613434 countsByYear W28946134342021 @default.
• W2894613434 countsByYear W28946134342022 @default.
• W2894613434 crossrefType "journal-article" @default.
• W2894613434 hasAuthorship W2894613434A5010476642 @default.
• W2894613434 hasAuthorship W2894613434A5042350728 @default.
• W2894613434 hasAuthorship W2894613434A5044800574 @default.
• W2894613434 hasAuthorship W2894613434A5074261771 @default.
• W2894613434 hasAuthorship W2894613434A5089050904 @default.
• W2894613434 hasBestOaLocation W28946134342 @default.
• W2894613434 hasConcept C104317684 @default.
• W2894613434 hasConcept C15152581 @default.

• next