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- W2894616023 abstract "Introduction: In patients diagnosed with incidental gallbladder cancer (iGBC), the benefit of re-resection remains unclear. The aim of this study was to analyze outcomes in patients who underwent completion radical cholecystectomy following a diagnosis of iGBC and to determine factors associated with residual disease on final histopathology and recurrence free survival. Methods: A retrospective analysis of patients with incidental GC between June 2010 and January 2017 was performed. Data covering demographic features, histological features of initial surgery and presence of residual disease on final histopathology and recurrence were analyzed. Results: Twenty eight patients underwent completion surgery following diagnosis of T1b/T2 gallbladder cancer at initial cholecystectomy, 9 of whom (34.6%) were found to have residual disease. Sixteen percent (2/12) and 44% (7/16) of patients with T1b and T2 cancers had residual disease on re-resection respectively (p value not significant). Preoperative imaging findings were not predictive of residual disease at surgery. Presence of residual disease at second surgery in T1b/T2 disease was associated with worse recurrence free survival (p < 0.05) and overall survival (p< 0.05) compared to no residual disease at surgery. Conclusion: Residual disease on re-resection is a grave sign. Residual disease correlated with T-stage and was the most relevant prognostic factor for survival. Re-resection for iGBC may be a mere staging procedure (subject to more number of patients and longer follow up).Tabled 1EP03B-007 overview of dataparametersNo Residual Disease at Second SurgeryResidual Disease at Second Surgeryp ValueCholecystectomyLaparoscopic1550.2089Open44T StageT1b1020.1359T297Pre-op CT ImagingOperable Residual Disease230.1484No residual disease176Recurrenceyes160.0004no183 Open table in a new tab" @default.
- W2894616023 created "2018-10-12" @default.
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- W2894616023 date "2018-09-01" @default.
- W2894616023 modified "2023-09-26" @default.
- W2894616023 title "Surgery in incidental gall bladder cancer – significance of residual disease" @default.
- W2894616023 doi "https://doi.org/10.1016/j.hpb.2018.06.1400" @default.
- W2894616023 hasPublicationYear "2018" @default.
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