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- W2894617457 abstract "SUMMARY The outcome of viral infection is extremely heterogeneous, with infected cells only sometimes activating innate immunity. Here we develop a new approach to assess how the genetic variation inherent in viral populations contributes to this heterogeneity. We do this by determining both the transcriptome and full-length sequences of all viral genes in single influenza-infected cells. Most cells are infected by virions with defects such as amino-acid mutations, internal deletions, or failure to express a gene. We identify instances of each type of defect that increase the likelihood that a cell activates an innate-immune response. However, immune activation remains stochastic in cells infected by virions with these defects, and sometimes occurs even when a cell is infected by a virion that expresses unmutated copies of all genes. Our work shows that viral genetic variation substantially contributes to but does not fully explain the heterogeneity in single influenza-infected cells." @default.
- W2894617457 created "2018-10-12" @default.
- W2894617457 creator A5001432379 @default.
- W2894617457 creator A5013316579 @default.
- W2894617457 creator A5091068534 @default.
- W2894617457 date "2018-10-07" @default.
- W2894617457 modified "2023-10-01" @default.
- W2894617457 title "Single-cell virus sequencing of influenza infections that trigger innate immunity" @default.
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- W2894617457 doi "https://doi.org/10.1101/437277" @default.
- W2894617457 hasPublicationYear "2018" @default.
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