FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894619360> ?p ?o ?g. }

• W2894619360 endingPage "174" @default.
• W2894619360 startingPage "170" @default.
• W2894619360 abstract "Summary Objective B lymphocyte activating factor (BAFF), a member of the tumour necrosis factor superfamily, is essential for B cell activation, differentiation and survival. Elevated circulating BAFF levels have been found in patients with several autoimmune conditions, including Graves’ disease. In addition, BAFF gene variants have been associated with Graves’ disease in a Taiwanese cohort, and with several other autoimmune conditions in non‐Taiwanese populations. Design and methods We performed a case‐control association study to investigate two BAFF polymorphisms ( rs9514828 and rs4000607 ) in a UK cohort of 444 patients with Graves’ disease. Genotype frequencies were compared to those from 447 local controls and more than 5000 healthy controls from the Wellcome Trust case‐control consortium (WTCCC2). Results There was a significant difference in the frequency of the AA genotype at rs4000607 between the Graves’ disease cohort and both the local controls ( P = 0.045) and the WTCCC2 controls ( P = 4.56 × 10 −6 ). Furthermore, the frequency of the A allele was found to be increased in the Graves’ disease group compared to WTCCC2 controls ( P = 0.02, OR 1.20 (95% CI 1.03‐1.41). No association was observed at the rs9514828 locus. Conclusion Dysfunction of the humoral immune system is an obligatory pathophysiological component of Graves’ disease, hence BAFF is an excellent functional candidate gene. We have demonstrated, for the first time, a significant association of the BAFF polymorphism rs4000607 with Graves’ disease in a UK cohort. Further work to elucidate the role of BAFF in the pathogenesis of Graves’ disease is now warranted." @default.
• W2894619360 created "2018-10-12" @default.
• W2894619360 creator A5029243250 @default.
• W2894619360 creator A5029347332 @default.
• W2894619360 creator A5037933965 @default.
• W2894619360 creator A5038848300 @default.
• W2894619360 creator A5055839993 @default.
• W2894619360 creator A5057478856 @default.
• W2894619360 creator A5082408868 @default.
• W2894619360 creator A5089617303 @default.
• W2894619360 creator A5090484443 @default.
• W2894619360 creator A5090684742 @default.
• W2894619360 date "2018-11-05" @default.
• W2894619360 modified "2023-10-09" @default.
• W2894619360 title "Analysis of BAFF gene polymorphisms in UK Graves’ disease patients" @default.
• W2894619360 cites W1985369577 @default.
• W2894619360 cites W1991523626 @default.
• W2894619360 cites W1994095884 @default.
• W2894619360 cites W2000160483 @default.
• W2894619360 cites W2014086244 @default.
• W2894619360 cites W2030447006 @default.
• W2894619360 cites W2038431971 @default.
• W2894619360 cites W2068040418 @default.
• W2894619360 cites W2068802249 @default.
• W2894619360 cites W2082697930 @default.
• W2894619360 cites W2091850111 @default.
• W2894619360 cites W2102544162 @default.
• W2894619360 cites W2102872217 @default.
• W2894619360 cites W2108065192 @default.
• W2894619360 cites W2118355604 @default.
• W2894619360 cites W2127971170 @default.
• W2894619360 cites W2135167801 @default.
• W2894619360 cites W2151655407 @default.
• W2894619360 cites W2161633633 @default.
• W2894619360 cites W2170025624 @default.
• W2894619360 cites W2343166692 @default.
• W2894619360 cites W2346324193 @default.
• W2894619360 cites W2394869660 @default.
• W2894619360 cites W2520353719 @default.
• W2894619360 cites W2588655590 @default.
• W2894619360 cites W2609734256 @default.
• W2894619360 cites W2610534492 @default.
• W2894619360 cites W2786928529 @default.
• W2894619360 cites W2806804338 @default.
• W2894619360 cites W2846558072 @default.
• W2894619360 cites W2891236135 @default.
• W2894619360 cites W4250359879 @default.
• W2894619360 cites W4361807026 @default.
• W2894619360 doi "https://doi.org/10.1111/cen.13872" @default.
• W2894619360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30281845" @default.
• W2894619360 hasPublicationYear "2018" @default.
• W2894619360 type Work @default.
• W2894619360 sameAs 2894619360 @default.
• W2894619360 citedByCount "14" @default.
• W2894619360 countsByYear W28946193602019 @default.
• W2894619360 countsByYear W28946193602020 @default.
• W2894619360 countsByYear W28946193602021 @default.
• W2894619360 countsByYear W28946193602022 @default.
• W2894619360 countsByYear W28946193602023 @default.
• W2894619360 crossrefType "journal-article" @default.
• W2894619360 hasAuthorship W2894619360A5029243250 @default.
• W2894619360 hasAuthorship W2894619360A5029347332 @default.
• W2894619360 hasAuthorship W2894619360A5037933965 @default.
• W2894619360 hasAuthorship W2894619360A5038848300 @default.
• W2894619360 hasAuthorship W2894619360A5055839993 @default.
• W2894619360 hasAuthorship W2894619360A5057478856 @default.
• W2894619360 hasAuthorship W2894619360A5082408868 @default.
• W2894619360 hasAuthorship W2894619360A5089617303 @default.
• W2894619360 hasAuthorship W2894619360A5090484443 @default.
• W2894619360 hasAuthorship W2894619360A5090684742 @default.
• W2894619360 hasConcept C104317684 @default.
• W2894619360 hasConcept C126322002 @default.
• W2894619360 hasConcept C134018914 @default.
• W2894619360 hasConcept C135763542 @default.
• W2894619360 hasConcept C146304588 @default.
• W2894619360 hasConcept C159654299 @default.
• W2894619360 hasConcept C170286685 @default.
• W2894619360 hasConcept C180754005 @default.
• W2894619360 hasConcept C203014093 @default.
• W2894619360 hasConcept C2776652619 @default.
• W2894619360 hasConcept C2778453870 @default.
• W2894619360 hasConcept C2779075594 @default.
• W2894619360 hasConcept C2779134260 @default.
• W2894619360 hasConcept C2780130043 @default.
• W2894619360 hasConcept C2780942790 @default.
• W2894619360 hasConcept C37463918 @default.
• W2894619360 hasConcept C54355233 @default.
• W2894619360 hasConcept C71924100 @default.
• W2894619360 hasConcept C72563966 @default.
• W2894619360 hasConcept C86803240 @default.
• W2894619360 hasConcept C8891405 @default.
• W2894619360 hasConceptScore W2894619360C104317684 @default.
• W2894619360 hasConceptScore W2894619360C126322002 @default.
• W2894619360 hasConceptScore W2894619360C134018914 @default.
• W2894619360 hasConceptScore W2894619360C135763542 @default.
• W2894619360 hasConceptScore W2894619360C146304588 @default.
• W2894619360 hasConceptScore W2894619360C159654299 @default.
• W2894619360 hasConceptScore W2894619360C170286685 @default.

• next