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• W2894621837 abstract "Abstract Incorporation of mismatched nucleotides during DNA replication or repair leads to transition or transversion mutations and is considered as a predominant source of base substitution mutagenesis in cancer cells. Watson-Crick like dG:dT base pairing is considered to be an important source of genome instability. Here we show that DNA polymerase (pol) μ insertion of 7,8-dihydro-8′-oxo-dGTP (8-oxodGTP) or deoxyguanosine triphosphate (dGTP) into a model double-strand break DNA repair substrate with template base T results in efficient ligation by DNA ligase. These results indicate that pol μ-mediated dGTP mismatch insertion opposite template base T coupled with ligation could be a feature of mutation prone nonhomologous end joining during double-strand break repair." @default.
• W2894621837 created "2018-10-12" @default.
• W2894621837 creator A5045523035 @default.
• W2894621837 creator A5088710468 @default.
• W2894621837 date "2018-10-11" @default.
• W2894621837 modified "2023-10-14" @default.
• W2894621837 title "Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate" @default.
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• W2894621837 doi "https://doi.org/10.1038/s41467-018-06700-5" @default.
• W2894621837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6181931" @default.
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