FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894623831> ?p ?o ?g. }

• W2894623831 endingPage "780" @default.
• W2894623831 startingPage "768" @default.
• W2894623831 abstract "Grass carp (Ctenopharyngodon idellus) hemorrhagic disease (GCHD), caused by grass carp reovirus (GCRV), has given rise to an enormous loss in grass carp industry during the past years. Up to date, vaccination remained to be the most effective way to protect grass carp from GCHD. Oral vaccination is of major interest due to its advantages of noninvasive, time-saving, and easily-operated. The introduction of oral vaccination has profound impact on aquaculture industry because of its feasibility of extensive application for fish in various size and age. However, the main challenge in developing oral vaccine is that antigens are easily degraded and are easy to induce tolerance. Bacillus subtilis (B. subtilis) spores would be an ideal oral vaccine delivery system for their robust specialty, gene operability, safety and adjuvant property. VP4 protein is the major outer capsid protein encoded by GCRV segment 6 (S6), which plays an important role in viral invasion and replication. In this study, we used B. subtilis spores as the oral delivery system and successfully constructed the B. subtilis CotC-VP4 recombinant spores (CotC-VP4 spores) to evaluate its protective efficacy in grass carp. Grass carp orally immunized with CotC-VP4 spores showed a survival rate of 57% and the relative percent survival (RPS) of 47% after the viral challenge. Further, the specific IgM levels in serum and the specific IgZ levels in intestinal mucus were significantly higher in the CotC-VP4 group than those in the Naive group. The immune-related genes including three innate immune-related genes (IL-4/13A, IL-4/13B, CSF1R), four adaptive immune-related genes (BAFF, CD4L, MHC-II, CD8), three inflammation-related genes (IL-1β, TNF-α, TGF-β) and interferon type I (IFN-I) related signaling pathway genes were significantly up-regulated in the CotC-VP4 group. The study demonstrated that the CotC-VP4 spores produced protection in grass carp against GCRV infection, and triggered both innate and adaptive immunity post oral immunization. This work highlighted that Bacillus subtilis spores were powerful platforms for oral vaccine delivery, and the combination of Bacillus subtilis spores with GCRV VP4 protein was a promising oral vaccine." @default.
• W2894623831 created "2018-10-12" @default.
• W2894623831 creator A5007261771 @default.
• W2894623831 creator A5019489953 @default.
• W2894623831 creator A5027605982 @default.
• W2894623831 creator A5027958721 @default.
• W2894623831 creator A5028680864 @default.
• W2894623831 creator A5039030237 @default.
• W2894623831 creator A5042387426 @default.
• W2894623831 creator A5045172994 @default.
• W2894623831 creator A5046570640 @default.
• W2894623831 creator A5052732570 @default.
• W2894623831 creator A5065678081 @default.
• W2894623831 creator A5069381616 @default.
• W2894623831 creator A5072699786 @default.
• W2894623831 creator A5076944335 @default.
• W2894623831 date "2019-01-01" @default.
• W2894623831 modified "2023-10-14" @default.
• W2894623831 title "Oral delivery of Bacillus subtilis spores expressing grass carp reovirus VP4 protein produces protection against grass carp reovirus infection" @default.
• W2894623831 cites W1004962528 @default.
• W2894623831 cites W1513604776 @default.
• W2894623831 cites W1965342008 @default.
• W2894623831 cites W1965642537 @default.
• W2894623831 cites W1967696649 @default.
• W2894623831 cites W1971878456 @default.
• W2894623831 cites W1972868629 @default.
• W2894623831 cites W1982514550 @default.
• W2894623831 cites W1983595394 @default.
• W2894623831 cites W1985825481 @default.
• W2894623831 cites W1999660917 @default.
• W2894623831 cites W1999878830 @default.
• W2894623831 cites W2013897297 @default.
• W2894623831 cites W2026240178 @default.
• W2894623831 cites W2027385417 @default.
• W2894623831 cites W2029981309 @default.
• W2894623831 cites W2031388429 @default.
• W2894623831 cites W2031489614 @default.
• W2894623831 cites W2036669717 @default.
• W2894623831 cites W2040112602 @default.
• W2894623831 cites W2041623659 @default.
• W2894623831 cites W2042433863 @default.
• W2894623831 cites W2058822011 @default.
• W2894623831 cites W2059039847 @default.
• W2894623831 cites W2063310200 @default.
• W2894623831 cites W2063641548 @default.
• W2894623831 cites W2069630043 @default.
• W2894623831 cites W2070841084 @default.
• W2894623831 cites W2072628432 @default.
• W2894623831 cites W2075683397 @default.
• W2894623831 cites W2078575853 @default.
• W2894623831 cites W2080702535 @default.
• W2894623831 cites W2081508444 @default.
• W2894623831 cites W2082665670 @default.
• W2894623831 cites W2089178087 @default.
• W2894623831 cites W2104171140 @default.
• W2894623831 cites W2104863857 @default.
• W2894623831 cites W2107277218 @default.
• W2894623831 cites W2121336765 @default.
• W2894623831 cites W2123183408 @default.
• W2894623831 cites W2155048276 @default.
• W2894623831 cites W2157407782 @default.
• W2894623831 cites W2257311854 @default.
• W2894623831 cites W2281564361 @default.
• W2894623831 cites W2343805865 @default.
• W2894623831 cites W2508764913 @default.
• W2894623831 cites W2528310573 @default.
• W2894623831 cites W256056509 @default.
• W2894623831 cites W2564619337 @default.
• W2894623831 cites W2572213178 @default.
• W2894623831 cites W2595376611 @default.
• W2894623831 cites W2604540918 @default.
• W2894623831 cites W2622800396 @default.
• W2894623831 cites W2751286428 @default.
• W2894623831 cites W2760266544 @default.
• W2894623831 cites W2790371671 @default.
• W2894623831 cites W2790448569 @default.
• W2894623831 cites W2802094749 @default.
• W2894623831 cites W2804640468 @default.
• W2894623831 cites W2884449845 @default.
• W2894623831 doi "https://doi.org/10.1016/j.fsi.2018.10.008" @default.
• W2894623831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300738" @default.
• W2894623831 hasPublicationYear "2019" @default.
• W2894623831 type Work @default.
• W2894623831 sameAs 2894623831 @default.
• W2894623831 citedByCount "35" @default.
• W2894623831 countsByYear W28946238312019 @default.
• W2894623831 countsByYear W28946238312020 @default.
• W2894623831 countsByYear W28946238312021 @default.
• W2894623831 countsByYear W28946238312022 @default.
• W2894623831 countsByYear W28946238312023 @default.
• W2894623831 crossrefType "journal-article" @default.
• W2894623831 hasAuthorship W2894623831A5007261771 @default.
• W2894623831 hasAuthorship W2894623831A5019489953 @default.
• W2894623831 hasAuthorship W2894623831A5027605982 @default.
• W2894623831 hasAuthorship W2894623831A5027958721 @default.
• W2894623831 hasAuthorship W2894623831A5028680864 @default.
• W2894623831 hasAuthorship W2894623831A5039030237 @default.
• W2894623831 hasAuthorship W2894623831A5042387426 @default.

• next