Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894627311> ?p ?o ?g. }
- W2894627311 abstract "ABSTRACT Pervasive transcription is a widespread phenomenon leading to the production of a plethora of non-coding RNAs (ncRNAs) without apparent function. Pervasive transcription poses a risk that needs to be controlled to prevent the perturbation of gene expression. In yeast, the highly conserved helicase Sen1 restricts pervasive transcription by inducing termination of non-coding transcription. However, the mechanisms underlying the specific function of Sen1 at ncRNAs are poorly understood. Here we identify a motif in an intrinsically disordered region of Sen1 that mimics the phosphorylated carboxy terminal domain (CTD) of RNA polymerase II and characterize structurally its recognition by the CTD-interacting domain of Nrd1, an RNA-binding protein that binds specific sequences in ncRNAs. In addition, we show that Sen1-dependent termination strictly requires the recognition of the CTD by the N-terminal domain of Sen1. We provide evidence that the Sen1-CTD interaction does not promote Sen1 initial recruitment but rather the capacity of Sen1 to induce the release of paused RNAPII from the DNA. Our results shed light onto the network of protein-protein interactions that control termination of non-coding transcription by Sen1." @default.
- W2894627311 created "2018-10-12" @default.
- W2894627311 creator A5035489993 @default.
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- W2894627311 creator A5077061322 @default.
- W2894627311 date "2018-10-03" @default.
- W2894627311 modified "2023-10-18" @default.
- W2894627311 title "Termination of non-coding transcription in yeast relies on both a CTD-interaction domain and a CTD-mimic in Sen1" @default.
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- W2894627311 doi "https://doi.org/10.1101/433045" @default.
- W2894627311 hasPublicationYear "2018" @default.
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