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- W2894628462 abstract "To date, investigations of executive function (EF) have focused on the prefrontal cortex (PFC), and prominent theories of EF are framed with respect to this brain region. Multiple theories describe a hierarchical functional organization for the lateral PFC, with anterior aspects controlling more abstract, higher-order behaviors (e.g., goal updating) and more posterior portions controlling more concrete, lower-order behaviors (e.g., response updating). However, recent evidence has indicated that the cerebellum (CB) also plays a role in EF. Posterior CB regions (Crus I & II) show structural and functional connections with the PFC, and further, resting networks including these CB regions are associated with individual differences in EF in healthy adults. However, it is unclear whether the cerebellum shows a similar functional gradient as does the PFC. To shed light on this issue we investigated high-resolution resting-state data from 225 participants in the Human Connectome Project. We compared the networks of Crus I, Crus II, and Lobule VI using standard GLM statistics. Demonstrating preliminary evidence for parallel PFC and cerebellar gradients, Crus I was functionally connected with anterior PFC, Crus II with middle PFC, and Lobule VI with posterior PFC. While no behavior was examined in the current study, the patterns of connectivity support the need for future functional neuroimaging investigations into functional gradients within the cerebellum. Moreover, the current results suggest that the cerebellum plays an important role in EF." @default.
- W2894628462 created "2018-10-12" @default.
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- W2894628462 date "2018-10-03" @default.
- W2894628462 modified "2023-09-24" @default.
- W2894628462 title "Dissociable Prefrontal-Cerebellar Networks Underlying Executive Function: Evidence from Resting State Functional Connectivity in the Human Connectome Project" @default.
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