FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894633807> ?p ?o ?g. }

• W2894633807 endingPage "2668" @default.
• W2894633807 startingPage "2655" @default.
• W2894633807 abstract "The long-standing goal in the field of peptide antibiotics has been to design lead compounds that have a wide spectrum of excellent antibacterial activity but are nontoxic to human cells. Gram-negative and Gram-positive bacteria have very different membranes, which are additionally modified in some drug-resistant species, presenting a challenge for the design of a single membrane-active peptide able to adapt its conformation to various physical properties of membrane microenvironments. In this paper, we describe how a peptide sequence can be constructed starting from an adaptable dynamic turn tandem motif in a central location. The peptide, named flexampin, has been examined firstly by molecular dynamics simulations. It uses a flexible central motif and designed helix-forming cationic amphipathic arms to form a boomerang-like, L-shape, V-shape, and hairpin, super-secondary structures, whichever is the best in matching amphipathic and hydrophobic microenvironments it encounters. Secondly, activity measurements showed that flexampin is bactericidal at low micromolar concentrations against Gram-positive and Gram-negative strains including some multidrug resistant clinical isolates, while it is nontoxic for human circulating blood cells, does not cause DNA damage, and has good selectivity for bacterial cells in comparison to human cells. It is the first membrane-active peptide designed with the ability to self-adjust the orientation of its two cationic helical arms, 3D-hydrophobic moment, and dipole moment for obtaining a better grasp of anionic polar head groups at bacterial membrane surfaces. • In silico designed peptide can adjust its structure to membrane surface charge. • Flexible central hinge enables increased activity against bacterial strains. • Orientation & magnitude of dipole moment favor entrance into anionic membrane. • Molecular dynamics simulations connect structural changes to selectivity." @default.
• W2894633807 created "2018-10-12" @default.
• W2894633807 creator A5006591078 @default.
• W2894633807 creator A5021149376 @default.
• W2894633807 creator A5037484111 @default.
• W2894633807 creator A5046062996 @default.
• W2894633807 creator A5056961321 @default.
• W2894633807 creator A5061305415 @default.
• W2894633807 creator A5066968654 @default.
• W2894633807 creator A5068808729 @default.
• W2894633807 creator A5070905238 @default.
• W2894633807 creator A5071053002 @default.
• W2894633807 date "2018-12-01" @default.
• W2894633807 modified "2023-10-16" @default.
• W2894633807 title "Designed peptide with a flexible central motif from ranatuerins adapts its conformation to bacterial membranes" @default.
• W2894633807 cites W1031578623 @default.
• W2894633807 cites W1241388078 @default.
• W2894633807 cites W1488975227 @default.
• W2894633807 cites W1489340266 @default.
• W2894633807 cites W1556426250 @default.
• W2894633807 cites W1728413725 @default.
• W2894633807 cites W1964937304 @default.
• W2894633807 cites W1966224201 @default.
• W2894633807 cites W1970923132 @default.
• W2894633807 cites W1978503212 @default.
• W2894633807 cites W1979764309 @default.
• W2894633807 cites W1989998611 @default.
• W2894633807 cites W1991798321 @default.
• W2894633807 cites W1993137607 @default.
• W2894633807 cites W1993149340 @default.
• W2894633807 cites W1993447746 @default.
• W2894633807 cites W1995816895 @default.
• W2894633807 cites W1996260034 @default.
• W2894633807 cites W1996978558 @default.
• W2894633807 cites W1999143468 @default.
• W2894633807 cites W2007650837 @default.
• W2894633807 cites W2008708467 @default.
• W2894633807 cites W2011306790 @default.
• W2894633807 cites W2014035436 @default.
• W2894633807 cites W2016333004 @default.
• W2894633807 cites W2023938985 @default.
• W2894633807 cites W2026482455 @default.
• W2894633807 cites W2027154929 @default.
• W2894633807 cites W2029667189 @default.
• W2894633807 cites W2029882655 @default.
• W2894633807 cites W2032226429 @default.
• W2894633807 cites W2035266068 @default.
• W2894633807 cites W2037788435 @default.
• W2894633807 cites W2047399603 @default.
• W2894633807 cites W2047752672 @default.
• W2894633807 cites W2051621570 @default.
• W2894633807 cites W2054602599 @default.
• W2894633807 cites W2054867534 @default.
• W2894633807 cites W2060189458 @default.
• W2894633807 cites W2060320231 @default.
• W2894633807 cites W2066817543 @default.
• W2894633807 cites W2067174909 @default.
• W2894633807 cites W2069341829 @default.
• W2894633807 cites W2072886460 @default.
• W2894633807 cites W2076444761 @default.
• W2894633807 cites W2081090090 @default.
• W2894633807 cites W2081183202 @default.
• W2894633807 cites W2081693079 @default.
• W2894633807 cites W2082047232 @default.
• W2894633807 cites W2084377551 @default.
• W2894633807 cites W2085253549 @default.
• W2894633807 cites W2090023488 @default.
• W2894633807 cites W2092629964 @default.
• W2894633807 cites W2094092670 @default.
• W2894633807 cites W2095407378 @default.
• W2894633807 cites W2095855980 @default.
• W2894633807 cites W2097099115 @default.
• W2894633807 cites W2107572441 @default.
• W2894633807 cites W2114711439 @default.
• W2894633807 cites W2119993590 @default.
• W2894633807 cites W2123172081 @default.
• W2894633807 cites W2123231250 @default.
• W2894633807 cites W2123768693 @default.
• W2894633807 cites W2126902508 @default.
• W2894633807 cites W2127522551 @default.
• W2894633807 cites W2128572087 @default.
• W2894633807 cites W2139915497 @default.
• W2894633807 cites W2146271266 @default.
• W2894633807 cites W2147454197 @default.
• W2894633807 cites W2151672044 @default.
• W2894633807 cites W2154692845 @default.
• W2894633807 cites W2160376610 @default.
• W2894633807 cites W2160947340 @default.
• W2894633807 cites W2169054000 @default.
• W2894633807 cites W2171559274 @default.
• W2894633807 cites W2171816984 @default.
• W2894633807 cites W2403862021 @default.
• W2894633807 cites W2548152519 @default.
• W2894633807 cites W2550675241 @default.
• W2894633807 cites W2555538399 @default.
• W2894633807 cites W2605666810 @default.
• W2894633807 cites W2801615077 @default.
• W2894633807 cites W562421102 @default.

• next