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• W2894636440 abstract "Basal ganglia play a pivotal role in procedural memory. However, the correlation between skill learning and striatal ¹²³I-ioflupane uptake in Parkinson's disease (PD) has not been reported previously. Our objective was to determine whether visuomotor skill learning is associated with striatal ¹²³I-ioflupane uptake in early PD.We designed a case-control study to assess learning and consolidation of a visuomotor learning task (mirrored drawing of star-shaped figures) performed on two consecutive days by early-PD patients (disease duration <2 years) and age-matched healthy subjects. Outcomes were the error rate and time per trial, as well as performance indices to assess the relative improvement on the first day (learning) and the retention on the second day (consolidation). For PD patients, we evaluated the correlation of skill learning with semiquantitative ¹²³I-ioflupane uptake.We included 9 PD patients and 10 control subjects with the same baseline characteristics (age, male/female ratio, educational level, Mini Mental State Examination score, and Hospital Anxiety and Depression Scale score, all p>0.18) other than the score on part III of the Movement Disorders Society Unified Parkinson's Disease Rating Scale, which was higher in the PD patients (mean±SD: 15.0±10.4 vs. 1.3±1.1, p<0.001). The learning indices were the same in the two groups (p>0.5), whereas PD patients showed a lower consolidation index for the time per trial (p=0.009). Moreover, this performance was correlated with uptake in the right caudate nucleus (Spearman's rho=0.82, p=0.007) and the right striatum (Spearman's rho=0.67, p=0.049), including when multiple linear regression adjusting for the levodopa equivalent daily dose was performed (p=0.005 for the caudate nucleus and p=0.024 for the striatum).This study provides evidence of a correlation between procedural memory impairment and striatal dopaminergic dysfunction in early PD." @default.
• W2894636440 created "2018-10-12" @default.
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• W2894636440 date "2018-01-01" @default.
• W2894636440 modified "2023-10-15" @default.
• W2894636440 title "Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson's Disease" @default.
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• W2894636440 doi "https://doi.org/10.3988/jcn.2018.14.4.505" @default.
• W2894636440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172506" @default.
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