Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894638217> ?p ?o ?g. }
- W2894638217 endingPage "811" @default.
- W2894638217 startingPage "803" @default.
- W2894638217 abstract "Many publications reported that genetic dysfunction mediates abnormal immune responses in the brain, which is important for the development of neurodegenerative diseases, especially for Parkinson’s disease (PD). This immune disorder results in subsequent inflammatory reaction, which stimulates microglia or other immune cells to secrete cytokines and chemokines and disturbs the proportion of peripheral blood lymphocyte subsets contributing to dopaminergic (DA) neuron apoptosis. Furthermore, the abnormal immune related signal pathways caused by genetic variants promote chronic inflammation destroying the blood–brain barrier, which allows infiltration of different molecules and blood cells into the central nervous system (CNS) exerting toxicity on DA neurons. As a result, the inflammatory reaction in the CNS accelerates the progression of Parkinson’s disease and promotes α-synuclein aggregation and diffusion among DA neurons in the procession of Parkinson’s disease. Thus, for disease evaluation, the genetic mediated abnormal immune response in PD may be assessed based on the multiple immune molecules and inflammatory factors, as well as the ratio of lymphocyte subsets from PD patient’s peripheral blood as potential biomarkers." @default.
- W2894638217 created "2018-10-12" @default.
- W2894638217 creator A5007226104 @default.
- W2894638217 creator A5008863671 @default.
- W2894638217 creator A5009978777 @default.
- W2894638217 creator A5016715629 @default.
- W2894638217 creator A5022512665 @default.
- W2894638217 creator A5032265903 @default.
- W2894638217 creator A5039054794 @default.
- W2894638217 creator A5054687857 @default.
- W2894638217 creator A5057261336 @default.
- W2894638217 creator A5071775313 @default.
- W2894638217 creator A5072714534 @default.
- W2894638217 creator A5076768386 @default.
- W2894638217 creator A5080508147 @default.
- W2894638217 creator A5085039487 @default.
- W2894638217 creator A5088985343 @default.
- W2894638217 date "2018-10-05" @default.
- W2894638217 modified "2023-10-17" @default.
- W2894638217 title "Gene Dysfunction Mediates Immune Response to Dopaminergic Degeneration in Parkinson’s Disease" @default.
- W2894638217 cites W1529674879 @default.
- W2894638217 cites W1606763503 @default.
- W2894638217 cites W1753183749 @default.
- W2894638217 cites W1770378670 @default.
- W2894638217 cites W1966918485 @default.
- W2894638217 cites W1977553663 @default.
- W2894638217 cites W1982310131 @default.
- W2894638217 cites W1986611577 @default.
- W2894638217 cites W1999639946 @default.
- W2894638217 cites W2000924812 @default.
- W2894638217 cites W2005356215 @default.
- W2894638217 cites W2006497054 @default.
- W2894638217 cites W2021533801 @default.
- W2894638217 cites W2025810715 @default.
- W2894638217 cites W2030995912 @default.
- W2894638217 cites W2042218080 @default.
- W2894638217 cites W2042735193 @default.
- W2894638217 cites W2044037509 @default.
- W2894638217 cites W2049733399 @default.
- W2894638217 cites W2063807467 @default.
- W2894638217 cites W2070847731 @default.
- W2894638217 cites W2073449985 @default.
- W2894638217 cites W2073845471 @default.
- W2894638217 cites W2082861241 @default.
- W2894638217 cites W2085419002 @default.
- W2894638217 cites W2090336391 @default.
- W2894638217 cites W2091478649 @default.
- W2894638217 cites W2091868439 @default.
- W2894638217 cites W2108565475 @default.
- W2894638217 cites W2111464898 @default.
- W2894638217 cites W2119098586 @default.
- W2894638217 cites W2132884035 @default.
- W2894638217 cites W2137829901 @default.
- W2894638217 cites W2138900023 @default.
- W2894638217 cites W2141459724 @default.
- W2894638217 cites W2148731774 @default.
- W2894638217 cites W2149698238 @default.
- W2894638217 cites W2151477002 @default.
- W2894638217 cites W2151513507 @default.
- W2894638217 cites W2162800670 @default.
- W2894638217 cites W2165465283 @default.
- W2894638217 cites W2168463955 @default.
- W2894638217 cites W2178147107 @default.
- W2894638217 cites W2189595531 @default.
- W2894638217 cites W2281906935 @default.
- W2894638217 cites W2310305711 @default.
- W2894638217 cites W2324979234 @default.
- W2894638217 cites W2325263169 @default.
- W2894638217 cites W2333668820 @default.
- W2894638217 cites W2340005882 @default.
- W2894638217 cites W2431987552 @default.
- W2894638217 cites W2483273953 @default.
- W2894638217 cites W2503377259 @default.
- W2894638217 cites W2521844563 @default.
- W2894638217 cites W2523905541 @default.
- W2894638217 cites W2524215672 @default.
- W2894638217 cites W2528919078 @default.
- W2894638217 cites W2529564975 @default.
- W2894638217 cites W2557700397 @default.
- W2894638217 cites W2560411827 @default.
- W2894638217 cites W2561506846 @default.
- W2894638217 cites W2574264100 @default.
- W2894638217 cites W2579122492 @default.
- W2894638217 cites W2604231034 @default.
- W2894638217 cites W2605685784 @default.
- W2894638217 cites W2614383142 @default.
- W2894638217 cites W2614921949 @default.
- W2894638217 cites W2618767189 @default.
- W2894638217 cites W2619801104 @default.
- W2894638217 cites W2638382976 @default.
- W2894638217 cites W2727554405 @default.
- W2894638217 cites W2728889421 @default.
- W2894638217 cites W2735647123 @default.
- W2894638217 cites W2736599890 @default.
- W2894638217 cites W2739441634 @default.
- W2894638217 cites W2752406006 @default.
- W2894638217 cites W2752710053 @default.
- W2894638217 cites W2752981360 @default.