Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894640317> ?p ?o ?g. }
- W2894640317 endingPage "22" @default.
- W2894640317 startingPage "17" @default.
- W2894640317 abstract "The age of checkpoint blockage emphasizes the importance of adaptive antitumor immune responses. This arm of immune defense is key in recognizing molecules via specific receptors to distinguish between self and foreign or mutated structures. Antigen-specific T-cells identify non-self epitopes, tumor-associated antigens, or neoepitopes on tumors to carry out attacks on malignant cells. Although tumor cells are immunogenic by nature, they have developed strategies to evade an immune response that would otherwise facilitate their clearance. Several steps in antitumor immunity utilize the toxic and signaling properties of reactive oxygen and nitrogen species (ROS/RNS). Cold physical plasmas are potent generators of such ROS/RNS and are demonstrated to have profound antitumor activity in vitro and in vivo. Here we discuss recent evidence and concepts on how plasmas may boost immunity against pathological cells. Specifically, plasma treatment may enhance the immunogenicity of tumor cells by induction of the immunogenic cancer cell death (ICD) and redox regulation of the antigen-presenting machinery. These aspects provide a rationale for localized plasma-based onco-therapies enhancing systemic antitumor immunity, which eventually may target distant tumor metastasis in cancer patients in a T-cell dependent fashion." @default.
- W2894640317 created "2018-10-12" @default.
- W2894640317 creator A5008566199 @default.
- W2894640317 creator A5053623492 @default.
- W2894640317 creator A5057079770 @default.
- W2894640317 date "2018-12-01" @default.
- W2894640317 modified "2023-10-16" @default.
- W2894640317 title "Potentiating anti-tumor immunity with physical plasma" @default.
- W2894640317 cites W1530610894 @default.
- W2894640317 cites W1583028397 @default.
- W2894640317 cites W1655860314 @default.
- W2894640317 cites W179238286 @default.
- W2894640317 cites W1964298091 @default.
- W2894640317 cites W1966657187 @default.
- W2894640317 cites W1978133924 @default.
- W2894640317 cites W1980734840 @default.
- W2894640317 cites W1995744610 @default.
- W2894640317 cites W2011458181 @default.
- W2894640317 cites W2015326650 @default.
- W2894640317 cites W2015776459 @default.
- W2894640317 cites W2016612145 @default.
- W2894640317 cites W2016789384 @default.
- W2894640317 cites W2016983859 @default.
- W2894640317 cites W2019447967 @default.
- W2894640317 cites W2025694904 @default.
- W2894640317 cites W2029342214 @default.
- W2894640317 cites W2036069120 @default.
- W2894640317 cites W2040392199 @default.
- W2894640317 cites W2046597185 @default.
- W2894640317 cites W2047447331 @default.
- W2894640317 cites W2050514979 @default.
- W2894640317 cites W2053194632 @default.
- W2894640317 cites W2054205907 @default.
- W2894640317 cites W2055388057 @default.
- W2894640317 cites W2062813847 @default.
- W2894640317 cites W2064058305 @default.
- W2894640317 cites W2068005505 @default.
- W2894640317 cites W2073621589 @default.
- W2894640317 cites W2075660588 @default.
- W2894640317 cites W2075772275 @default.
- W2894640317 cites W2083685984 @default.
- W2894640317 cites W2086854995 @default.
- W2894640317 cites W2090917172 @default.
- W2894640317 cites W2092595468 @default.
- W2894640317 cites W2093902610 @default.
- W2894640317 cites W2096433384 @default.
- W2894640317 cites W2108585076 @default.
- W2894640317 cites W2111344966 @default.
- W2894640317 cites W2113812682 @default.
- W2894640317 cites W2114569569 @default.
- W2894640317 cites W2120426523 @default.
- W2894640317 cites W2121626779 @default.
- W2894640317 cites W2129303473 @default.
- W2894640317 cites W2129509656 @default.
- W2894640317 cites W2136570726 @default.
- W2894640317 cites W2138651252 @default.
- W2894640317 cites W2145220191 @default.
- W2894640317 cites W2149057253 @default.
- W2894640317 cites W2151659223 @default.
- W2894640317 cites W2156606232 @default.
- W2894640317 cites W2159334325 @default.
- W2894640317 cites W2159854818 @default.
- W2894640317 cites W2165064047 @default.
- W2894640317 cites W2165461617 @default.
- W2894640317 cites W2172383460 @default.
- W2894640317 cites W2173709855 @default.
- W2894640317 cites W2259278905 @default.
- W2894640317 cites W2288284945 @default.
- W2894640317 cites W2340558243 @default.
- W2894640317 cites W2416880410 @default.
- W2894640317 cites W2460855605 @default.
- W2894640317 cites W2527013454 @default.
- W2894640317 cites W2529326852 @default.
- W2894640317 cites W2536322725 @default.
- W2894640317 cites W2547825706 @default.
- W2894640317 cites W2548757381 @default.
- W2894640317 cites W2564105093 @default.
- W2894640317 cites W2564192806 @default.
- W2894640317 cites W2568510753 @default.
- W2894640317 cites W2574931933 @default.
- W2894640317 cites W2584195395 @default.
- W2894640317 cites W2584779890 @default.
- W2894640317 cites W2618209346 @default.
- W2894640317 cites W2622392048 @default.
- W2894640317 cites W2624207812 @default.
- W2894640317 cites W2733200382 @default.
- W2894640317 cites W2744365083 @default.
- W2894640317 cites W2746757303 @default.
- W2894640317 cites W2757153533 @default.
- W2894640317 cites W2760737924 @default.
- W2894640317 cites W2762577984 @default.
- W2894640317 cites W2770376025 @default.
- W2894640317 cites W2791898833 @default.
- W2894640317 cites W2797967795 @default.
- W2894640317 cites W2808343073 @default.
- W2894640317 doi "https://doi.org/10.1016/j.cpme.2018.10.001" @default.
- W2894640317 hasPublicationYear "2018" @default.
- W2894640317 type Work @default.