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- W2894646512 endingPage "3122" @default.
- W2894646512 startingPage "3098" @default.
- W2894646512 abstract "Low Voltage-Activated (LVA) T-type calcium channels are characterized by transient current and Low Threshold Spikes (LTS) that trigger neuronal firing and oscillatory behavior. Combined with their preferential localization in dendrites and their specific “window current”, T-type calcium channels are considered to be key players in signal amplification and synaptic integration. Assisted by the emerging pharmacological tools, the structural determinants of channel gating and kinetics, as well as novel physiological and pathological functions of T-type calcium channels, are being uncovered. In this review, we provide an overview of structural determinants in T-type calcium channels, their involvement in disorders and diseases, the development of novel channel modulators, as well as Structure-Activity Relationship (SAR) studies that lead to rational drug design." @default.
- W2894646512 created "2018-10-12" @default.
- W2894646512 creator A5025539645 @default.
- W2894646512 creator A5033658079 @default.
- W2894646512 creator A5046085342 @default.
- W2894646512 date "2020-06-04" @default.
- W2894646512 modified "2023-10-16" @default.
- W2894646512 title "T-type Calcium Channels in Health and Disease" @default.
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