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- W2894650306 abstract "Macroautophagy, commonly referred to as autophagy, is a recycling process involving lysosomal degradation of the cell components such as proteins and organelles. This process prevents damage to the cell through the degradation of nonfunctional cellular components and provides raw material and energy which are required to realize biosynthesis reactions. Since autophagy has evolutionarily conserved complex molecular mechanisms, the relationship between autophagy and cancer is multifaceted. There are some insights in which autophagy, also referred to as type 2 cell death, has been suggested as an alternative approach to kill cancer cells have defected apoptosis mechanism. On the other hand, it has also been shown in recent studies that autophagy mechanism, especially in cancer stem cells, may be responsible for obtaining epithelial–mesenchymal transition, invasion, metastasis, drug resistance and recurrence. This chapter focuses on the role of autophagy mechanisms on cancer stem cells and its place in future treatment approaches." @default.
- W2894650306 created "2018-10-12" @default.
- W2894650306 creator A5001692156 @default.
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- W2894650306 date "2018-01-01" @default.
- W2894650306 modified "2023-10-18" @default.
- W2894650306 title "Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives" @default.
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- W2894650306 doi "https://doi.org/10.1007/978-3-319-98146-8_11" @default.
- W2894650306 hasPublicationYear "2018" @default.
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