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• W2894655850 abstract "Abstract The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. Importantly, glycan N301 shields V3 loop and CD4 binding site epitopes from neutralising antibodies. Here, we use molecular dynamics techniques to evaluate the structural rearrangements that maintain the protective qualities of the glycan shield after the loss of glycan N301. We examined a naturally occurring subtype C isolate and its N301A mutant; the mutant not only remained protected against neutralising antibodies targeting underlying epitopes, but also exhibited an increased resistance to the VRC01 class of broadly neutralising antibodies. Analysis of this mutant revealed several glycans that were responsible, independently or through synergy, for the neutralisation resistance of the mutant. These data provide detailed insight into the glycan shield’s ability to compensate for the loss of a glycan, as well as the cascade of glycan movements on a protomer, starting at the point mutation, that affects the integrity of an antibody epitope located at the edge of the diminishing effect. These results present key, previously overlooked, considerations for HIV-1 Env glycan research and related vaccine studies." @default.
• W2894655850 created "2018-10-12" @default.
• W2894655850 creator A5011012168 @default.
• W2894655850 creator A5020128637 @default.
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• W2894655850 creator A5086719622 @default.
• W2894655850 date "2018-10-09" @default.
• W2894655850 modified "2023-10-15" @default.
• W2894655850 title "Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan" @default.
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• W2894655850 doi "https://doi.org/10.1038/s41598-018-33390-2" @default.
• W2894655850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6177452" @default.
• W2894655850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30302011" @default.
• W2894655850 hasPublicationYear "2018" @default.
• W2894655850 type Work @default.
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