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• W2894661543 abstract "Kidney regeneration from pluripotent stem cells is receiving a lot of attention because limited treatments are currently available for chronic kidney disease (CKD). It has been shown that uremic state in CKD is toxic to somatic stem/progenitor cells, such as endothelial progenitor and mesenchymal stem cells, affecting their differentiation and angiogenic potential. Recent studies reported that specific abnormalities caused by the non-inherited disease are often retained in induced pluripotent stem cell (iPSC)-derived products obtained from patients. Thus, it is indispensable to first assess whether iPSCs derived from patients with CKD due to non-inherited disease (CKD-iPSCs) have the ability to generate kidneys. In this study, we generated iPSCs from patients undergoing haemodialysis due to diabetes nephropathy and glomerulonephritis (HD-iPSCs) as representatives of CKD-iPSCs or from healthy controls (HC-iPSCs). HD-iPSCs differentiated into nephron progenitor cells (NPCs) with similar efficiency to HC-iPSCs. Additionally, HD-iPSC-derived NPCs expressed comparable levels of NPC markers and differentiated into vascularised glomeruli upon transplantation into mice, as HC-iPSC-derived NPCs. Our results indicate the potential of HD-iPSCs as a feasible cell source for kidney regeneration. This is the first study paving the way for CKD patient-stem cell-derived kidney regeneration, emphasising the potential of CKD-iPSCs." @default.
• W2894661543 created "2018-10-12" @default.
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• W2894661543 date "2018-10-08" @default.
• W2894661543 modified "2023-10-03" @default.
• W2894661543 title "Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration" @default.
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• W2894661543 doi "https://doi.org/10.1038/s41598-018-33256-7" @default.
• W2894661543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6175865" @default.
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• W2894661543 hasPublicationYear "2018" @default.
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