FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894670147> ?p ?o ?g. }

• W2894670147 endingPage "11354" @default.
• W2894670147 startingPage "11347" @default.
• W2894670147 abstract "Ile-Trp-His-His-Thr (IWHHT), initially identified as an ACE inhibitory peptide, was shown to have antioxidant and anti-inflammatory activities in cells and blood pressure lowering activity in animals. IWHHT was degraded into IWH and IW during simulated gastrointestinal digestion. The purpose of this study was to investigate the stability, permeability, and transport pathways of IWHHT, IWH, and IW across intestinal epithelium using human intestinal Caco-2 cell monolayers. IWHHT, IWH, and IW were partly degraded by aminopeptidase N or dipeptidyl peptidase IV, but they were transported intact, with apparent permeability coefficients of (22.0 ± 1.42) × 10-8, (37.5 ± 1.11) × 10-8, and (19.6 ± 0.62) × 10-8 cm s-1, respectively. The results firstly evidenced an important role of aminopeptidase N in cleaving small ACE inhibitory peptides during transport. IWH was transported via both peptide transporter 1 (PepT1) and paracellular route, while IW was via PepT1 and IWHHT was via paracellular route only. Transport of IW implied that hydrophobic peptides (even with a small size), consisting of only highly hydrophobic amino acid residues, might not be transported via paracellular diffusion. This study suggested that all three peptides could pass through the intestinal epithelium and that the degraded IWH and IW might also contribute to the antihypertensive activity of IWHHT." @default.
• W2894670147 created "2018-10-12" @default.
• W2894670147 creator A5036320219 @default.
• W2894670147 creator A5061628794 @default.
• W2894670147 creator A5066294676 @default.
• W2894670147 creator A5088599082 @default.
• W2894670147 date "2018-10-03" @default.
• W2894670147 modified "2023-10-13" @default.
• W2894670147 title "Stability and Transport of Spent Hen-Derived ACE-Inhibitory Peptides IWHHT, IWH, and IW in Human Intestinal Caco-2 Cell Monolayers" @default.
• W2894670147 cites W1799666420 @default.
• W2894670147 cites W197645179 @default.
• W2894670147 cites W1984153473 @default.
• W2894670147 cites W1987046956 @default.
• W2894670147 cites W1992364351 @default.
• W2894670147 cites W1996042213 @default.
• W2894670147 cites W1997922972 @default.
• W2894670147 cites W2003859016 @default.
• W2894670147 cites W2008173042 @default.
• W2894670147 cites W2009845088 @default.
• W2894670147 cites W2028273867 @default.
• W2894670147 cites W2034190295 @default.
• W2894670147 cites W2039665384 @default.
• W2894670147 cites W2052418725 @default.
• W2894670147 cites W2053357438 @default.
• W2894670147 cites W2058596949 @default.
• W2894670147 cites W2064627397 @default.
• W2894670147 cites W2076185711 @default.
• W2894670147 cites W2078593198 @default.
• W2894670147 cites W2083416343 @default.
• W2894670147 cites W2085484568 @default.
• W2894670147 cites W2087169338 @default.
• W2894670147 cites W2097519121 @default.
• W2894670147 cites W2111729861 @default.
• W2894670147 cites W2121836743 @default.
• W2894670147 cites W2125012638 @default.
• W2894670147 cites W2158970031 @default.
• W2894670147 cites W2203774030 @default.
• W2894670147 cites W2228216144 @default.
• W2894670147 cites W2263141344 @default.
• W2894670147 cites W2273684385 @default.
• W2894670147 cites W2333604692 @default.
• W2894670147 cites W2398752419 @default.
• W2894670147 cites W2509921038 @default.
• W2894670147 cites W2516118414 @default.
• W2894670147 cites W2550720962 @default.
• W2894670147 cites W2602025036 @default.
• W2894670147 cites W2612061396 @default.
• W2894670147 cites W2743803043 @default.
• W2894670147 cites W2782020873 @default.
• W2894670147 cites W2800028985 @default.
• W2894670147 cites W2888205131 @default.
• W2894670147 cites W4232529163 @default.
• W2894670147 cites W974254039 @default.
• W2894670147 doi "https://doi.org/10.1021/acs.jafc.8b03956" @default.
• W2894670147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30280571" @default.
• W2894670147 hasPublicationYear "2018" @default.
• W2894670147 type Work @default.
• W2894670147 sameAs 2894670147 @default.
• W2894670147 citedByCount "28" @default.
• W2894670147 countsByYear W28946701472019 @default.
• W2894670147 countsByYear W28946701472020 @default.
• W2894670147 countsByYear W28946701472021 @default.
• W2894670147 countsByYear W28946701472022 @default.
• W2894670147 countsByYear W28946701472023 @default.
• W2894670147 crossrefType "journal-article" @default.
• W2894670147 hasAuthorship W2894670147A5036320219 @default.
• W2894670147 hasAuthorship W2894670147A5061628794 @default.
• W2894670147 hasAuthorship W2894670147A5066294676 @default.
• W2894670147 hasAuthorship W2894670147A5088599082 @default.
• W2894670147 hasConcept C120882062 @default.
• W2894670147 hasConcept C1491633281 @default.
• W2894670147 hasConcept C185592680 @default.
• W2894670147 hasConcept C193176779 @default.
• W2894670147 hasConcept C2776580952 @default.
• W2894670147 hasConcept C2779281246 @default.
• W2894670147 hasConcept C2780985610 @default.
• W2894670147 hasConcept C2781077229 @default.
• W2894670147 hasConcept C41625074 @default.
• W2894670147 hasConcept C515207424 @default.
• W2894670147 hasConcept C529295009 @default.
• W2894670147 hasConcept C54355233 @default.
• W2894670147 hasConcept C55493867 @default.
• W2894670147 hasConcept C60903277 @default.
• W2894670147 hasConcept C86803240 @default.
• W2894670147 hasConceptScore W2894670147C120882062 @default.
• W2894670147 hasConceptScore W2894670147C1491633281 @default.
• W2894670147 hasConceptScore W2894670147C185592680 @default.
• W2894670147 hasConceptScore W2894670147C193176779 @default.
• W2894670147 hasConceptScore W2894670147C2776580952 @default.
• W2894670147 hasConceptScore W2894670147C2779281246 @default.
• W2894670147 hasConceptScore W2894670147C2780985610 @default.
• W2894670147 hasConceptScore W2894670147C2781077229 @default.
• W2894670147 hasConceptScore W2894670147C41625074 @default.
• W2894670147 hasConceptScore W2894670147C515207424 @default.
• W2894670147 hasConceptScore W2894670147C529295009 @default.
• W2894670147 hasConceptScore W2894670147C54355233 @default.
• W2894670147 hasConceptScore W2894670147C55493867 @default.
• W2894670147 hasConceptScore W2894670147C60903277 @default.

• next